AI Article Synopsis
- Wound healing research is crucial for understanding conditions like fibrosis, but the link between skin microbiota and fibrosis is not well understood.
- The study focuses on keloids, a challenging fibrotic skin disease, and shows the presence of microbiota in keloid tissues, revealing differences in microbial composition compared to normal skin.
- Findings indicate elevated levels of IL-8, which promotes collagen accumulation and fibroblast movement, suggesting that targeting commensal bacteria and IL-8 signaling could be key in treating recurrent keloid disease.
Article Abstract
Wound healing is an intensely studied topic involved in many relevant pathophysiological processes, including fibrosis. Despite the large interest in fibrosis, the network that is related to commensal microbiota and skin fibrosis remains mysterious. Here, we pay attention to keloid, a classical yet intractable skin fibrotic disease to establish the association between commensal microbiota to scaring tissue. Our histological data reveal the presence of microbiota in the keloids. 16S rRNA sequencing characterizes microbial composition and divergence between the pathological and normal skin tissues. Moreover, the data show elevation of interleukin-8 (IL-8) in both the circulation and keloid tissue, which elicited the collagen accumulation and migratory program of dermal fibroblasts via CXCR1/2 receptor. Our research provides insights into the pathology of human fibrotic diseases, advocating commensal bacteria and IL-8 signaling as useful targets in future interventions of recurrent keloid disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287872 | PMC |
| http://dx.doi.org/10.1093/pnasnexus/pgae273 | DOI Listing |
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