AI Article Synopsis
- * They discovered important signs of ageing and how they work together, which could help find ways to slow down or even reverse age-related diseases.
- * A special meeting called the Longevity Med Summit in May 2023 brought experts together to talk about how to improve our health as we get older and live healthier lives for more years.
Article Abstract
In recent years, there has been a paradigm shift with regards to ageing, challenging its traditional perception as an inevitable and natural process. Researchers have collectively identified hallmarks of ageing, nine of which were initially proposed in 2013 and expanded in 2023 to include disabled macroautophagy, chronic inflammation, and dysbiosis, enhancing our understanding of the ageing process at microscopic, cellular, and system-wide levels. Strategies to manipulate these hallmarks present opportunities for slowing, preventing, or reversing age-related diseases, thereby promoting longevity. The interdependence of these hallmarks underscores the necessity of a comprehensive, systems-based approach to address the complex processes contributing to ageing. As a primary risk factor for various diseases, ageing diminishes healthspan, leading to extended periods of compromised health and multiple age-related conditions towards the end of life. The significant gap between healthspan and lifespan holds substantial economic and societal implications. The inaugural Longevity Med Summit (4-5 May 2023, Cascais, Portugal) provided an international forum to discuss the academic and industry landscape of healthy longevity research, preventive medicine and clinical practice to enhance healthspan.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286550 | PMC |
| http://dx.doi.org/10.3389/fragi.2024.1417455 | DOI Listing |
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