Integr Cancer Ther
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Published: July 2024
Objective: Powerful adjuvant strategies are required to improve the survival of patients with completely resected stage ΙΙΙA non-small cell lung cancer (NSCLC). We aimed to compare the efficacy of traditional Chinese medicine (TCM) treatment versus observation after adjuvant chemotherapy in these patients.
Methods: Eligible patients were randomized 1:1 to receive either oral decoctions based on Qi-Yin syndrome differentiation (TCM group) or observation (observation group). The intervention lasted for 12 months. The primary endpoint was 1-year disease-free survival (DFS). Secondary endpoints were DFS, quality of life, regulatory T cells (Tregs), and cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) on the surface of Tregs in peripheral blood. We used EORTC QLQ-LC43 to evaluate quality of life.
Results: Between Apr 29, 2019, and Nov 11, 2021, 75 patients were randomly assigned to oral decoctions based on Qi-Yin syndrome differentiation (n = 38) or observation (n = 37). The full analysis set included 35 patients in the TCM group and 35 in the observation group. After a median follow-up of 24.2 months, oral decoctions based on Qi-Yin syndrome differentiation improved DFS compared with observation (HR 0.378, 95% CI: 0.157-0.912; = .03). One-year DFS was 82.1% in the TCM group and 61.9% in the observation group ( = .06). Three months after randomization, scores of total health, role function, emotional function, and social function in the TCM group were higher than those in the observation group ( < .01 for all), scores of fatigue, pain, insomnia, appetite loss, constipation, cough, and chest pain were lower than those in the observation group ( < .05 for all); there was no significant difference in the proportion of Tregs between the TCM group and the observation group ( = .58); the proportion of CTLA-4Tregs in the TCM group was lower than that in the observation group ( = .046). There were no adverse events that occurred in both groups.
Conclusions: Oral decoctions based on Qi-Yin syndrome differentiation after adjuvant chemotherapy prolonged DFS, reduced the risk of disease recurrence and metastasis, improved quality of life, and down-regulated the proportion of CTLA-4Tregs in completely resected stage ΙΙΙA NSCLC patients.
Trial Registration: Chinese Clinical Trial Register, No. ChiCTR1800019396. Date of registration: 9 November 2018.
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http://dx.doi.org/10.1177/15347354241268271 | DOI Listing |
Adv Sci (Weinh)
December 2024
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, China.
Recent studies have highlighted the role of the gut microbiota in type 2 diabetes (T2D). Improving gut microbiota dysbiosis can be a potential strategy for the prevention and management of T2D. Here, this work finds that the abundance of Barnesiella intestinihominis is significantly decreased in the fecal of T2D patients from 2-independent centers.
View Article and Find Full Text PDFJ Ethnopharmacol
December 2024
Hospital Affiliated to Jiangxi University of Chinese Medicine, Nanchang, 330006, China; Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, 530011, China. Electronic address:
Ethnopharmacological Relevance: Traditional Chinese Medicine (TCM) has a history of thousands of years in China. The Tongfeng Qingxiao Formula (TFQXF), after decoction and oral administration, has shown significant therapeutic effects on Gouty arthritis (GA). TCM is often considered an experiential medicine, lacking modern scientific research, and the efficacy of TFQXF faces the same issue.
View Article and Find Full Text PDFInflammopharmacology
December 2024
Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100, Punjab, Pakistan.
Juice and decoction of leaves of Suaeda fruticosa, a halophytic medicinal plant of Cholistan desert, is traditionally used to treat rheumatism. The current study was carried out to probe into in vivo anti-nociceptive, anti-inflammatory, and anti-arthritic potential of ethanolic extract of the whole plant of S. fruticosa (Et-SF) and its bioactive molecules.
View Article and Find Full Text PDFTrop Med Health
December 2024
School of Life Sciences, College of Agriculture, Engineering and Science, University of KwaZulu-Natal, Westville, 4001, South Africa.
Background: Sub-Saharan Africa faces one of the highest burdens of venereal diseases (VDs) globally. This review aims to critically evaluate the existing literature on the diverse Indigenous knowledge and medicinal plants utilised for treating VDs in sub-Saharan Africa.
Methods: We used the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) protocol to guide the execution of the review.
Traditional Chinese medicine(TCM) has significant advantages in treatment of chronic kidney disease, but its clinical research evidence needs to be further summarized and improved. By means of evidence mapping, this paper systematically categorized the clinical research on TCM in treating chronic kidney disease in recent ten years, so as to understand the existing evidence level in this field and offer a reference for addressing current issues. The relevant literature published between January 1, 2013 and December 31, 2023 was systematically searched in both Chinese and English databases.
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