AI Article Synopsis
- Dinuclear iridium(III) complexes activated by light are promising for cancer therapy, but their use is limited due to poor tissue penetration and activation challenges.
- Researchers introduced a new approach using ultrasound-triggered near-infrared fluorescent dinuclear iridium(III) nanoparticles called NanoIr, which effectively inhibit tumor growth by generating reactive oxygen species.
- Combining NanoIr with cisplatin in ovarian cancer models shows enhanced therapeutic effects, demonstrating the potential of this strategy for immunogenic sonodynamic therapy.
Article Abstract
Dinuclear iridium(III) complexes activated by light-inducible spatiotemporal control are emerging as promising candidates for cancer therapy. However, broader applications of current light-activated dinuclear iridium(III) complexes are limited by the ineffective tissue penetration and undesirable feedback on guidance activation. Here, an ultrasound (US) triggered near infrared-fluorescent dinuclear iridium(III) nanoparticle, NanoIr, is first reported to precisely and spatiotemporally inhibit tumor growth. It is demonstrated that reactive oxygen species can be generated by NanoIr upon exposure to US irradiation (NanoIr + US), thereby inducing immunogenic cell death. When combined with cisplatin, NanoIr + US elicits synergistic effects in patient-derived tumor xenograft mice models of ovarian cancer. This work first provides a design of dinuclear iridium(III) nanoparticles for immunogenic sonodynamic therapy.
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| http://dx.doi.org/10.1002/adma.202406815 | DOI Listing |
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