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Adalimumab Use in Severe Recalcitrant Vulval Lichen Sclerosus and Vulval Lichen Planus.
J Low Genit Tract Dis
December 2024
Vulvar Disorders and Dermatology Unit, The Royal Women's Hospital, Parkville, Victoria, Australia.
Objectives: This case series aims to evaluate the demographic features, disease characteristics, and treatment outcomes of 8 patients receiving subcutaneous (SC) adalimumab for severe, refractory vulval lichen sclerosus (VLS) and/or vulval lichen planus (VLP). Both conditions are chronic inflammatory dermatoses that significantly impair quality of life, and although first-line treatment typically involves potent to ultrapotent topical corticosteroids, managing severe cases is challenging due to a lack of FDA-approved systemic therapies. Adalimumab, a TNF-α inhibitor, may offer a promising alternative by targeting the inflammatory cytokine implicated in the pathogenesis of both conditions.
View Article and Find Full Text PDFRapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
Association between atopic dermatitis and prurigo nodularis: a systematic review and meta-analysis.
Int J Dermatol
September 2024
Department of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
- Atopic dermatitis (AD) and prurigo nodularis (PN) are chronic skin conditions characterized by intense itching and eczema-like lesions, which significantly impact patients' quality of life.
- Recent research has shown a strong connection between AD and PN, with a meta-analysis revealing that individuals with PN have a much higher risk of developing AD (odds ratio of 16.85) and a notable prevalence of PN among those with AD (2.00%).
- These findings suggest a complex relationship between the two conditions that warrants further research to better understand their interactions and improve treatment approaches.
Neuroinflammation evoked mechanisms for neuropathic itch in the spared nerve injury mouse model of neuropathic pain.
Neuropharmacology
November 2024
Department of Neurosciences, Psychology, Drug Research and Child Health (Neurofarba), University of Florence, Viale G. Pieraccini 6, Florence, Italy. Electronic address:
A large portion of neuropathic pain suffering patients may also concurrently experience neuropathic itch, with a negative impact on the quality of life. The limited understanding of neuropathic itch and the low efficacy of current anti-itch therapies dictate the urgent need of a better comprehension of molecular mechanisms involved and development of relevant animal models. This study was aimed to characterize the itching phenotype in a model of trauma-induced peripheral neuropathy, the spared nerve injury (SNI), and the molecular events underlying the overlap with the nociceptive behavior.
View Article and Find Full Text PDFSkin microdialysis detects distinct immunologic patterns in chronic inflammatory skin diseases.
J Allergy Clin Immunol
December 2024
Department of Dermatology, Venereology and Allergology, University Medical Centre Göttingen (UMG), Göttingen, Germany.
Article Synopsis
- The study investigates inflammatory skin diseases by analyzing lesional and nonlesional skin using skin microdialysis to get better insights into their proteomic characteristics.
- Samples from patients with atopic dermatitis, psoriasis vulgaris, and prurigo nodularis were analyzed alongside healthy controls to identify differences in cytokine levels and metabolic processes.
- Key findings indicate that lesional skin from psoriasis and prurigo nodularis showed distinct proteomic profiles compared to nonlesional skin, with specific cytokines like IL-8, IL-22, MCP-1, and IL-12p40 potentially serving as biomarkers for these conditions.
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