AI Article Synopsis
- Inflammation is the body's natural response to injury or infection, but if it becomes chronic, it can lead to serious health issues like obesity, cancer, and heart disease.
- Chronic low-grade inflammation is increasingly common and is linked to rising global health problems, highlighting a pressing need for intervention.
- The review explores current understanding and knowledge gaps about chronic inflammation's role in various diseases and suggests future research directions to combat its effects.
Article Abstract
Inflammation is an important physiological response of the organism to restore homeostasis upon pathogenic or damaging stimuli. However, the persistence of the harmful trigger or a deficient resolution of the process can evolve into a state of low-grade, chronic inflammation. This condition is strongly associated with the development of several increasingly prevalent and serious chronic conditions, such as obesity, cancer, and cardiovascular diseases, elevating overall morbidity and mortality worldwide. The current pandemic of chronic diseases underscores the need to address chronic inflammation, its pathogenic mechanisms, and potential preventive measures to limit its current widespread impact. The present review discusses the current knowledge and research gaps regarding the association between low-grade chronic inflammation and chronic diseases, focusing on obesity, cardiovascular diseases, digestive diseases, and cancer. We examine the state of the art in selected aspects of the topic and propose future directions and approaches for the field.
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| http://dx.doi.org/10.1152/physiol.00021.2024 | DOI Listing |
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