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| http://dx.doi.org/10.1164/rccm.202406-1235LE | DOI Listing |
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A serum B-lymphocyte activation signature is a key distinguishing feature of the immune response in sarcoidosis compared to tuberculosis.
Commun Biol
September 2024
Laboratory Medical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Article Synopsis
- Sarcoidosis and tuberculosis (TB) are similar granulomatous diseases that can cause uveitis, prompting a study of inflammation-related proteins in serum from patients in the Netherlands (sarcoidosis) and Indonesia (TB).
- Researchers found 192 proteins unique to sarcoidosis and 102 unique to active pulmonary TB when compared to healthy controls, but noted overlapping immune pathways in both diseases.
- A specific B-lymphocyte activation signature linked to sarcoidosis was identified, distinguishing it from TB, indicating that B-cell signaling differences are a crucial immunological factor between the two conditions.
Sarcoidosis Immunodiagnostic Test Detects IgG Antibodies against Unique Antigenic Epitopes.
Am J Respir Crit Care Med
November 2024
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, Michigan; and.
The Applications of ELISpot in the Identification and Treatment of Various Forms of Tuberculosis and in the Cancer Immunotherapies.
Methods Mol Biol
March 2024
, Cellinfinitybio, San Francisco, CA, USA.
ELISpot (enzyme-linked immunospot) is a powerful immunological tool for the detection of cytokine-secreting cells at a single-cell resolution. It is widely used for the diagnosis of various infectious diseases, e.g.
View Article and Find Full Text PDFCirculating T cells in sarcoidosis have an aberrantly activated phenotype that correlates with disease outcome.
J Autoimmun
December 2024
Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Rationale: Disease course in sarcoidosis is highly variable. Bronchoalveolar lavage fluid and mediastinal lymph nodes show accumulation of activated T cells with a T-helper (Th)17.1 signature, which correlates with non-resolving sarcoidosis.
View Article and Find Full Text PDFInterferon-gamma Release Assay-positive Granulomatous Interstitial Nephritis in a Patient with a History of Diffuse Large B Cell Lymphoma.
Intern Med
June 2023
Division of Nephrology and Hypertension, the Jikei University School of Medicine, Japan.
Tuberculosis is a common etiology of granulomatous interstitial nephritis (GIN). However, the absence of evidence of lung involvement and lack of mycobacterial isolation in cultures make the etiological diagnosis and treatment decision challenging. We herein report a 46-year-old man with severe renal failure, a persistent fever, and a history of lymphoma.
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