Objective: To assess the clinical effectiveness of Yangxinshi (YXS) tablets on exercise capacity and symptoms of anxiety and depression in patients with coronary heart disease (CHD).
Methods And Results: A randomized, double-blind, placebo-controlled, multicenter clinical trial was performed to assess the effects of YXS tablets on exercise capacity and quality of life in patients with CHD. A total of 82 patients were included in this trial. Compared with the placebo group, the YXS group showed significant improvement in peak (0.22 L/min vs 0.01 L/min; difference 0.1, 95% confidence interval (CI) 0.04-0.16, = 0.000), peak Mets (0.58 vs 0.09; difference 0.3, 95% CI 0.12-0.47, = 0.005), anaerobic threshold (AT) (0.23 L/min vs 0.04 L/min; difference 0.12, 95% CI 0.07-0.18, = 0.000), AT Mets (0.62 vs 0.16; difference 0.35, 95% CI 0.2-0.5, = 0.001), and 6 minutes walking test (6MWT) (50.05 m vs 11.91 m; difference 29.92, 95% CI 18.78-41.07, = 0.000). There were no differences in Hamilton anxiety rating scale (HAM-A score (1.97 vs 2.07; difference 2.03, 95% CI 0.99-3.06, = 0.926) and Hamilton depression rating scale (HAM-D) score (1.06 vs 1.7; difference1.42, 95% CI 0.24-2.6, = 0.592).
Conclusions: In patients with CHD, YXS tablets, compared with placebo, could improve exercise capacity, without beneficial effects on anxiety and depression symptoms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266962 | PMC |
| http://dx.doi.org/10.31083/j.rcm2308266 | DOI Listing |
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