Background: This study aimed to explore the association between cardiac fibroblast activation and cardiac magnetic resonance (CMR) imaging parameters in patients with myocarditis following infection with coronavirus 2019 (COVID-19).
Methods: In this prospective study, four patients with COVID-19-related myocarditis underwent Tc-labeled-hydrazinonicotinamide-fibroblast activation protein inhibitor-04 (Tc-HFAPi) single photon emission computed tomography/computed tomography (SPECT/CT) and CMR imaging. Segmental Tc-HFAPi activity was quantified as the percentage of average segmental myocardial count global left ventricular target-to-background ratio. T1/T2 values, extracellular volume (ECV), and late gadolinium enhancement (LGE) were analyzed by CMR. The consistency between myocardial Tc-HFAPi activity and CMR parameters was explored.
Results: In patients with myocarditis, the proportion of segments with abnormal Tc-HFAPi activity was significantly higher than in those with abnormal LGE (81.25% vs. 60.93%, = 0.011), abnormal T2 (81.25% vs. 50.00%, 0.001), and abnormal ECV (81.25% vs. 59.38%, = 0.007); however, they were similar in those with abnormal native T1 (81.25% vs. 73.43%, = 0.291). Meanwhile, Tc-HFAPi imaging exhibited good consistency with native T1 (kappa = 0.69).
Conclusions: Increased cardiac Tc-HFAPi activity is present in COVID-19-related myocarditis, which is correlated with the native T1 values in CMR.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11267212 | PMC |
| http://dx.doi.org/10.31083/j.rcm2505161 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparison of Cardiac Activated Fibroblast Imaging and Magnetic Resonance Imaging in Patients with COVID-19-Related Myocarditis.
Rev Cardiovasc Med
May 2024
Department of Nuclear Medicine, Beijing Chaoyang Hospital, Capital Medical University, 100020 Beijing, China.
Background: This study aimed to explore the association between cardiac fibroblast activation and cardiac magnetic resonance (CMR) imaging parameters in patients with myocarditis following infection with coronavirus 2019 (COVID-19).
Methods: In this prospective study, four patients with COVID-19-related myocarditis underwent Tc-labeled-hydrazinonicotinamide-fibroblast activation protein inhibitor-04 (Tc-HFAPi) single photon emission computed tomography/computed tomography (SPECT/CT) and CMR imaging. Segmental Tc-HFAPi activity was quantified as the percentage of average segmental myocardial count global left ventricular target-to-background ratio.
Tc-HFAPi SPECT imaging predicts left ventricular remodeling after acute myocardial infarction.
J Nucl Cardiol
August 2024
Department of Cardiology, Cardiovascualr Imaging Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. Electronic address:
Background: Despite improved treatments for acute myocardial infarction (AMI), myocardial fibrosis remains a key driver of adverse left ventricular (LV) remodeling and increased mortality. Fibroblast activation and proliferation significantly contribute to this process by enhancing cardiac fibrosis, which can lead to detrimental changes in LV structure. This study evaluates the effectiveness of Tc-labeled fibroblast activation protein inhibitor (Tc-HFAPi) SPECT imaging in predicting LV remodeling over 12 months in post-AMI patients.
View Article and Find Full Text PDFMyocardial work by pressure-strain loop is associated with molecular imaging of fibroblast activation in hypertensive hearts using Tc-HFAPI SPECT.
Int J Cardiovasc Imaging
September 2024
Department of Ultrasound Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Tc-HFAPI can visualize fibroblast activation in hypertensive hearts. Myocardial work (MW) reflects the cardiac mechanical properties after accounting for the afterload in hypertensive patients. We investigated whether MW was associated with increased uptake of Tc-HFAPI.
View Article and Find Full Text PDFSynthesis and Preliminary Study of Tc-Labeled HYNIC-FAPi for Imaging of Fibroblast Activation Proteins in Tumors.
Mol Pharm
February 2024
Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun 130033, People's Republic of China.
Fibroblast activation protein (FAP) is an emerging target for cancer diagnosis. Different types of FAP inhibitor (FAPI)-based radiotracers have been developed and applied for tumor imaging. However, few FAPI tracers for single photon emission computed tomography (SPECT) imaging have been reported.
View Article and Find Full Text PDFTc-Labeled FAPI SPECT Imaging in Idiopathic Pulmonary Fibrosis: Preliminary Results.
Pharmaceuticals (Basel)
October 2023
Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China.
Aim: Idiopathic pulmonary fibrosis (IPF) is associated with a poor prognosis, presenting the most aggressive form of interstitial lung diseases (ILDs). Activated fibroblasts are crucial for pathological processes. Fibroblast activation protein (FAP) inhibitor (FAPI) tracers would be promising imaging agents for these diseases.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!