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| http://dx.doi.org/10.1002/emp2.13248 | DOI Listing |
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An ultra-conserved poison exon in the Tra2b gene encoding a splicing activator is essential for male fertility and meiotic cell division.
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Newcastle University Biosciences Institute (NUBI), Central Parkway, Newcastle University, NE1 3BZ, Newcastle upon Tyne, UK.
The cellular concentrations of splicing factors (SFs) are critical for controlling alternative splicing. Most serine and arginine-enriched (SR) protein SFs regulate their own concentration via a homeostatic feedback mechanism that involves regulation of inclusion of non-coding 'poison exons' (PEs) that target transcripts for nonsense-mediated decay. The importance of SR protein PE splicing during animal development is largely unknown despite PE ultra-conservation across animal genomes.
View Article and Find Full Text PDFSurprise Baby: Abdominoplasty Performed During Unknown Pregnancy.
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From the Department of Plastic, Aesthetic and Reconstructive Surgery, Hospital of the Brothers of St. John of God, Paracelsus Medical University, Salzburg, Austria.
Abdominoplasty is a commonly performed procedure for patients after significant weight loss and in postpregnancy women. Stable weight and completed family planning are critical for optimal outcomes, as pregnancy postabdominoplasty can increase risks for both mother and fetus and potentially compromise aesthetic results. We present the first reported case of a patient undergoing abdominoplasty while unknowingly pregnant.
View Article and Find Full Text PDFBiological relevance and methodological implications of unexpected hearing thresholds in a diving bird.
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Deutsches Meeresmuseum, Katharinenberg 14 - 20, 18439, Stralsund, Germany.
Many animals alternate between different media, such as air and water, thanks to specific adaptations. Among birds, penguins (Sphenisciformes) have the most extreme morphological, physiological, and behavioural adaptations to their amphibious lifestyle. Their auditory perception of sound, potentially matching different impedances in air and under water, is largely unknown particularly in terms of whether their underwater adaptations may have affected their in-air hearing capacity.
View Article and Find Full Text PDFRare but relevant: Nitrous oxide and peripheral neurotoxicity, what do we know?
Addiction
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Amsterdam UMC, Department of Psychiatry, University of Amsterdam, Amsterdam, The Netherlands.
Nitrous oxide (NO), used medically as an anaesthetic, has gained popularity as a recreational drug, with rising prevalence particularly among young adults. While its reinforcing and addictive potential remains debated, NO is proven to be neurotoxic, especially with prolonged, heavy use, which is often unexpected for users. The neurotoxicological mechanism underlying NO-induced neurotoxicity involves inactivation of vitamin B (cobalamin), which disrupts methionine synthesis, essential for maintaining the myelin sheath.
View Article and Find Full Text PDFCase report of anti-f(ce) antibody identified with unknown autoantibody from ABO discrepancy in a patient with liver cell carcinoma.
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Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:
The Rh blood type has 57 antigens, including D, C, E, c, and e. This blood type is clinically significant, alongside the ABO blood type. The anti-f(ce) antibody is an unexpected antibody that targets an antigen composed of the c and e antigens.
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