AI Article Synopsis
- IL-6 enhances tissue monitoring, mobility, and the ability of microglia to engulf debris, while IFN-⍺ reduces these functions in mouse microglia.
- *This research connects changes at the genetic level (transcriptome) with how microglia behave.
- *The findings could help pave the way for developing treatments for neuroinflammatory diseases driven by cytokines.
Article Abstract
Previous reports have shown that IL-6 and IFN-⍺ induce distinct transcriptomic and morphological changes in microglia. Here, we demonstrate that IL-6 increases tissue surveillance, migration and phagocytosis in primary murine microglia, whereas IFN-⍺ inhibits these functions. Our results provide a crucial link between transcriptome and function. It holds the potential to serve as the foundation for future studies aimed at identifying therapeutic targets for cytokine-mediated neuroinflammatory diseases.
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| http://dx.doi.org/10.1111/nan.13003 | DOI Listing |
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