It is widely believed that unfinished tasks are better remembered than finished tasks, a phenomenon labelled the "Zeigarnik-Effect." It has been argued that this advantage relies on the persisting tension inherent in uncompleted intentions. However, this interpretation has been challenged. First, the memory advantage could not be reliably replicated. Second, a memory advantage can still be observed when the unfinished status of an uncompleted intention is inherently terminated, rendering the "persisting tension" explanation unlikely. The goal of this study was to investigate the potential memory advantage of interrupted but finished tasks and its relation to the personality disposition achievement motivation, specifically, hope of success and fear of failure. This goal was motivated by the hypothesis that the experience of a discrepancy between the anticipation of success and the subsequent failure would relate to the memory for an unfinished task, and that this discrepancy experience would be stronger for people high in hope of success. A large sample of adults (>1,000 participants) was presented with 12 anagrams. If they did not solve an anagram within 60 s, they were shown the solution. Afterwards, we measured free recall of the anagram solutions and assessed achievement motivation. Overall, participants recalled more unsolved anagrams than solved anagrams. However, only individuals high in hope of success displayed a greater tendency to remember unsolved anagrams. This study supports the idea that a discrepancy experience rather than persisting tension coincides with memory for unsolved tasks.
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http://dx.doi.org/10.1177/17470218241269310 | DOI Listing |
Biomedicines
January 2025
Department of Hematology, Ion Chiricuta Oncology Institute, 400015 Cluj-Napoca, Romania.
The incidence rate of cutaneous melanoma is on the rise worldwide, due to increased exposure to UV radiation, aging populations, and exposure to teratogen agents. However, diagnosis is more precise, and the increased number of new cases is related to the improved diagnosis tools. Despite better early diagnosis and better therapies, melanoma has remained a significant public health challenge because of its aggressive behavior and high potential for metastasis.
View Article and Find Full Text PDFDiagnostics (Basel)
January 2025
Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.
This study aims to evaluate the management of oro-antral communications (OAC) and fistulas (OAF), focusing on treatment strategies based on defect size, epithelialization, and the presence of sinus infections, while exploring both traditional and emerging techniques. The systematic review was conducted following the PRISMA guidelines and registered on PROSPERO (CDR ID 623251). Using targeted keywords, articles in English published within the last 10 years were analyzed from databases such as PubMed, WoS and Scopus, selecting only clinical studies on human patients.
View Article and Find Full Text PDFEur Urol
January 2025
Department of Surgery, University of Cambridge, Cambridge, UK; Cancer Research UK Cambridge Centre, Cambridge Biomedical Campus, Cambridge, UK.
Neoadjuvant systemic treatment strategies have improved outcomes in several solid tumour types. This success has not yet been replicated in renal cell carcinoma (RCC). A consensus and international collaboration are urgently needed for the development of adaptive perioperative immunotherapy strategies for patients with RCC at high risk of recurrence.
View Article and Find Full Text PDFJ Med Chem
January 2025
State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211100, P. R. China.
Molecular glue degraders induce "undruggable" protein degradation by a proximity-induced effect. Inspired by the clinical success of immunomodulatory drugs, we aimed to design novel molecular glue degraders targeting GSPT1. Here, we report the design of a series of GSPT1 molecular glue degraders.
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January 2025
School of Medicine and Pharmacy, Duy Tan University, Da NangVietnam, Institute of Research and Development, Duy Tan University, Da Nang Vietnam.
Alzheimer's disease (AD) remains a significant challenge in neurology, marked by progressive cognitive decline and neurodegeneration. Despite extensive research efforts, effective treatments are still lacking. Traditional drug discovery is often slow and costly, frequently resulting in limited success.
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