AI Article Synopsis
- Cancer-associated fibroblasts (CAFs) play a key role in tumors by influencing growth, spread, recurrence, and resistance to treatments.
- Advances in sequencing technologies, particularly single-cell RNA sequencing, have improved the identification of CAFs, though issues like lacking a spatial context remain.
- Recent studies are combining spatial transcriptomics with single-cell analysis to better understand CAFs and how targeting them can help overcome problems like drug resistance, blood vessel formation, and cancer spread.
Article Abstract
Cancer-associated fibroblasts (CAFs) are the major components of the tumor microenvironment and are related to tumor proliferation, metastasis, relapse, and drug resistance. With the development of sequencing technologies, single-cell RNA sequencing has become a popular method for identifying CAFs in the tumor microenvironment. Whereas the drawbacks of CAFs, such as the lack of a spatial landscape, still exist, recent research has utilized spatial transcriptomics combined with single-cell RNA sequencing to address this issue. These multiomics analyses can resolve the single-cell resolution problem in spatial transcriptomics. In this review, we summarized the recent literature regarding the targeting of CAFs to address drug resistance, angiogenesis, metabolic reprogramming and metastasis in tumor tissue.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287900 | PMC |
| http://dx.doi.org/10.1186/s40364-024-00622-9 | DOI Listing |
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