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Insulin-like growth factor binding protein 7 identified in aged dental pulp by single-cell RNA sequencing.
J Adv Res
December 2024
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Operative Dentistry & Endodontics, School of Stomatology, Fourth Military Medical University, No.145 Western Changle Road, Xi'an, Shaanxi 710032, China. Electronic address:
Introduction: Aging influences the regenerative and reparative functions of dental pulp, and an in-depth and complete understanding of aged dental pulp is highly important.
Objective: This study aimed to explore the heterogeneity of young and aged dental pulp tissue via single-cell RNA sequencing (scRNA-seq), search novel markers of aged dental pulp, and further explore their mechanism.
Methods: ScRNA-seq was employed to analyze the heterogeneity of young and aged dental pulp tissue, and immunohistochemical staining was used to detect new marker Insulin-like Growth Factor Binding Protein 7 (IGFBP7) in aged dental pulp.
Meta-analysis of proteomics data from osteoblasts, bone, and blood: Insights into druggable targets, active factors, and potential biomarkers for bone biomaterial design.
J Tissue Eng
November 2024
Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.
Non-healing bone defects are a pressing public health concern accounting for one main cause for decreased life expectancy and quality. An aging population accompanied with increasing incidence of comorbidities, foreshadows a worsening of this socio-economic problem. Conventional treatments for non-healing bone defects prove ineffective for 5%-10% of fractures.
View Article and Find Full Text PDFIGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways.
Cell Commun Signal
November 2024
Department of Experimental Medicine, Luigi Vanvitelli Campania University, Naples, Italy.
Senescent cells exert their effects through the release of various factors, collectively referred to as the senescence-associated secretory phenotype (SASP). The SASP can induce senescence in healthy cells (secondary senescence), modulate immune system function, reshape the extracellular matrix, and facilitate cancer progression.Among SASP components, certain factors act as key regulators in the induction of secondary senescence.
View Article and Find Full Text PDFGastrointestinal permeability and kidney injury risk during hyperthermia in young and older adults.
Exp Physiol
January 2025
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.
We tested whether older adults, compared with young adults, exhibit greater gastrointestinal permeability and kidney injury during heat stress. Nine young (32 ± 3 years) and nine older (72 ± 3 years) participants were heated using a model of controlled hyperthermia (increasing core temperature by 2°C via a water-perfused suit). Gastrointestinal permeability was assessed using a multi-sugar drink test containing lactulose, sucrose and rhamnose.
View Article and Find Full Text PDFEndothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions.
Clin Sci (Lond)
August 2024
Department of Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, SC, U.S.A.
Article Synopsis
- Diabetes can lead to endothelial dysfunction and increase the risk of Alzheimer's disease by dysregulating the endothelin (ET) system, particularly ET-1's effect on brain microvascular pericytes (BMVPCs).
- In experiments mimicking diabetic conditions, ET-1 was found to induce cellular senescence in BMVPCs, evidenced by increased senescence markers and altered cellular phenotype, showing a potential link between ET-1 and inflammatory responses.
- The study suggests that blocking ETA receptors can mitigate the effects of ET-1 on BMVPCs, indicating that further in vivo research is necessary to understand the implications for vascular cognitive impairment and dementia (VCID).
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