This scientific commentary refers to ‘NMDA receptor autoantibodies primarily impair the extrasynaptic compartment’ by Jamet (https://doi.org/10.1093/brain/awae163).

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11292893PMC
http://dx.doi.org/10.1093/brain/awae236DOI Listing

Publication Analysis

Top Keywords

autoimmune 'secondary
4
'secondary synaptopathies'
4
synaptopathies' nmdar
4
nmdar antibodies
4
antibodies primary
4
primary extra-synaptopathy?
4
extra-synaptopathy? scientific
4
scientific commentary
4
commentary refers
4
refers ‘nmda
4

Similar Publications

Subglottic stenosis (SGS) presents a rare, yet challenging condition characterized by airway obstruction below the glottis, with diverse etiologies ranging from congenital to acquired factors like intubation or autoimmune diseases. Diagnosis and management of SGS during pregnancy are particularly complex due to limited literature and diagnostic consensus. This article presents a case of a 26-year-old pregnant woman presenting with escalating dyspnea and stridor attributed to SGS, most likely secondary to idiopathic etiology.

View Article and Find Full Text PDF

Boosting human immunology: harnessing the potential of immune organoids.

EMBO Mol Med

January 2025

Medical Clinic III for Oncology, Hematology, Immuno-Oncology and Rheumatology, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.

Studying the human immune system in vivo is challenging and often not possible. Therefore, most human immunology studies have been predominantly confined to peripheral blood analyses, which by themselves have inherent limitations, as many immune reactions take place within tissues. For example, potent antibody responses that contribute to fighting infections and provide protection following vaccination require cellular interactions between B cells and T cells in specialized micro-anatomical structures called germinal centers, which are found in secondary lymphoid organs such as spleen, lymph nodes, and tonsils.

View Article and Find Full Text PDF

Human Kv1.3, encoded by , is expressed in neuronal and immune cells. Its impaired expression or function produces chronic inflammatory disease and autoimmune disorders, the severity of which correlates with Kv1.

View Article and Find Full Text PDF

Sickle cell anemia (SCA) is one of the known hemoglobinopathies that result in red blood cell (RBC) destruction, among other complications. There are factors that make SCA an environment for autoimmune disease (AID). They include chronic inflammation, immune-mediated processes involved in SCA complications, and susceptibility to infections.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!