AI Article Synopsis
- FDG-PET/MRI has been studied since 2011 as a potential tool to enhance colorectal cancer care, but research gaps still exist.
- A systematic review analyzed 22 studies from 2000 to 2023, assessing FDG-PET/MRI's effectiveness in initial staging, restaging, and detecting metastasis compared to standard imaging methods.
- Results indicated that FDG-PET/MRI is superior in detecting distant metastatic disease, with a significant impact on management decisions; however, its technological limitations suggest standard imaging methods should remain primary.
Article Abstract
Purpose: Since its introduction in 2011, FDG-PET/MRI has been advocated as a useful adjunct in colorectal cancer care. However, gaps and limitations in current research remain. This systematic review aims to review the current literature to quantify the utility of FDG-PET/MRI in colorectal cancer care.
Methods: An up-to-date review was performed on the available literature between 2000 and 2023 on PubMed, EMBASE, Medline, databases. All studies reporting on the use of FDG-PET/MRI in colorectal cancer care were analyzed. The main outcome measures were accuracy in initial staging, restaging, and detection of metastatic disease in both rectal as well as colon cancers. The secondary outcome was comparing the performance of FDG-PET/MRI versus Standard of Care Imaging (SCI). Finally, the clinical significance of FDG-PET/MRI was measured in the change in management resulting from imaging findings.
Results: A total of 22 observational studies were included, accounting for 988 patients. When individually compared to current Standard of Care Imaging (SCI)-MRI pelvis for rectal cancer and thoraco-abdominal contrast CT, PET/MRI proved superior in terms of distant metastatic disease detection. This led to as much as 21.0% change in management. However, the technological limitations of PET/MRI were once again highlighted, suggesting SCI should retain its place as first-line imaging.
Conclusion: FDG-PET/MRI appears to be a promising adjunct in staging and restaging of colorectal cancer in carefully selected patients.
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| http://dx.doi.org/10.1007/s00261-024-04460-z | DOI Listing |
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