AI Article Synopsis
- - Peutz-Jeghers syndrome (PJS) is a genetic condition that usually appears in childhood and increases the risk of certain cancers, marked by symptoms like oral freckles and intestinal polyps.
- - Boys with PJS can develop large-cell calcifying Sertoli cell tumors, which produce estrogen and may lead to issues like growth spurts and breast enlargement.
- - The authors share three cases where gynecomastia (breast enlargement) in male PJS patients improved on its own without treatment, suggesting that monitoring the condition might be a feasible management strategy.
Article Abstract
Peutz-Jeghers syndrome (PJS) is a childhood-onset cancer predisposition syndrome that is associated with oral freckling and gastrointestinal polyposis. Male patients with PJS are at risk for large-cell calcifying Sertoli cell tumors in childhood. These tumors are estrogen-producing and can cause symptoms of precocious puberty, gynecomastia, and growth acceleration. Here we discuss our experience with spontaneous resolution or stabilization of breast enlargement without medical intervention in three patients with PJS and gynecomastia. These cases indicate that a watchful waiting approach can be considered in the management of gynecomastia in male children with PJS.
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| http://dx.doi.org/10.1002/pbc.31180 | DOI Listing |
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