[Patients with long-term survival in malignant gliomas after photodynamic therapy].

Objective: Analysis of long-lived patients from the group of patients with glioblastomas after using photodynamic therapy in the structure of their complex treatment in order to assess the influence of various factors on their life expectancy.

Material And Methods: In total, a single-center, retrospective categorical study analyzed the long-term results of treatment of 63 patients with glioblastoma in the structure of complex treatment including photodynamic therapy. Clinical factors (age, sex, number of cases, preoperative Karnofsky index, location and size of the tumor, radicality of the operation), histological (nuclear polymorphism, mitosis, vascular proliferation, necrosis), immunohistochemical (Ki-67, p53 index) molecular-genetic factors (expression of ), amount of radiation and chemotherapy were analyzed.

Results: In the entire group of patients, there was a direct correlation of life expectancy with status, status, the number of courses of chemotherapy, the age of the patient, and the severity of the first surgical intervention.

Conclusion: Clinical features such as age at diagnosis and extent of surgical resection and amount of chemotherapy have predictive value in assessing their effect on life expectancy. Mutations in and promoter methylation were the most important molecular factors determining long-term patient survival.