To identify potential antischistosomal agents through 3D pharmacophore-based virtual screening of US FDA approved drugs. A comprehensive virtual screening was conducted on a dataset of 10,000 FDA approved drugs, employing praziquantel as a template. Promising candidates were selected and assessed for their impact on viability and using infected mice. Among the selected drugs, betamethasone and doxazosin demonstrated efficacy, with effective concentration 50% (EC) values ranging from 35 to 60 μM. studies revealed significant (>50%) reductions in worm burden for both drugs. These findings suggest that betamethasone and doxazosin hold promise for repurposing in treating schistosomiasis. Additionally, the study showcases a useful approach for identifying new antischistosomal drugs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457623 | PMC |
| http://dx.doi.org/10.1080/17568919.2024.2379231 | DOI Listing |
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