We have successfully prepared the titanium dioxide (TiO) nanoparticles (NPs) and sulfur-incorporated graphitic carbon nitride (S-GCN)-modified carbon paste electrode (CPE). The CPEs modified with TiO NPs and S-GCN were employed for detecting and quantifying the skeletal muscle relaxant cyclobenzaprine hydrochloride (CBP) using cyclic voltammetry and square wave voltammetry (SWV) techniques. Optimal electrochemical conditions were indicated by the pH study results, with the highest peak current observed at a physiological pH of 7.4. The electrochemical process was determined to involve an equivalent number of protons (H) and electrons (e). The concentration variation of CBP (ranging from 0.06 to 10 × 10 mol L) was explored using SWV. The limits of detection and quantification were determined as 6.4 × 10 and 2.1 × 10 M, respectively. The proposed electrode configuration was applied to analyze real samples, including water, biomedical, and pharmaceutical specimens.
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http://dx.doi.org/10.1021/acsomega.4c02158 | DOI Listing |
Chest
November 2024
Pulmonology and Critical Care, Northeast Georgia Medical Center, Gainesville, GA.
A 52-year-old woman with a history of leiomyoma uteri and tobacco-use disorder in remission presented with 2 months of progressive back pain. Her pain was located between her shoulder blades and was described as constant with intermittent sharp, stabbing sensation. It was nonradiating and aggravated by inspiration.
View Article and Find Full Text PDFJAMA Netw Open
September 2024
Challenges in Managing and Preventing Pain Clinical Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
Importance: Stricter opioid prescribing guidelines have increased prescriptions of skeletal muscle relaxants (SMRs) for chronic pain, but the efficacy of long-term use of SMRs for chronic pain is unknown.
Objective: To systematically review the effectiveness or efficacy of long-term use of SMRs for chronic pain.
Evidence Review: Two reviewers systematically searched Ovid MEDLINE, Embase (Ovid), Web of Science, CINAHL, and Cochrane through December 4, 2023.
ACS Omega
July 2024
Department of Metallurgical and Materials Engineering, Bartin University, Bartin 74100, Turkey.
We have successfully prepared the titanium dioxide (TiO) nanoparticles (NPs) and sulfur-incorporated graphitic carbon nitride (S-GCN)-modified carbon paste electrode (CPE). The CPEs modified with TiO NPs and S-GCN were employed for detecting and quantifying the skeletal muscle relaxant cyclobenzaprine hydrochloride (CBP) using cyclic voltammetry and square wave voltammetry (SWV) techniques. Optimal electrochemical conditions were indicated by the pH study results, with the highest peak current observed at a physiological pH of 7.
View Article and Find Full Text PDFJ Craniofac Surg
July 2024
Department of Surgery, Creighton University School of Medicine.
Botulinum toxin has been increasingly studied and used for varying conditions, most notably, cosmetics. However, it has been shown that botulinum toxin demonstrates a high efficacy in treating spasticity disorders throughout the body, including the face. Facial spasms vary in pathophysiology, region, and severity.
View Article and Find Full Text PDFSr Care Pharm
July 2024
2 Upstate Community Hospital, Pharmacy Department, Syracuse, New York.
In older inpatients, anticholinergic medications can increase the risk of complications that may increase length of stay (LOS). Cyclobenzaprine is an anticholinergic medication associated with mental status changes, falls, and injuries in older patients. The purpose of this study is to determine whether use of a lower cyclobenzaprine dose (5 mg) compared with higher dosing (10 mg) will affect LOS, 30-day readmission rates, and need for injectable psychotropic agents in inpatients 65 years of age and older.
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