AI Article Synopsis
- * Lenvatinib is the primary treatment for advanced HCC, but many patients develop resistance, complicating the selection of effective second-line therapies.
- * This case report highlights the first instance in the literature of a lenvatinib-resistant HCC patient who responded positively to lenalidomide, suggesting a potential new treatment option.
Article Abstract
Hepatocellular carcinoma (HCC) is one of the most aggressive types of cancer. Although it has a high mortality rate, there is currently no effective treatment for HCC. Lenvatinib has traditionally been used as the first-line treatment for advanced HCC (aHCC); however, resistance to this therapy is common. It can be difficult to select effective second-line drugs to overcome lenvatinib resistance when treating aHCC. For patients with aHCC, poor treatment efficacy can result in patients missing the optimal treatment window and can lead to an irreversible situation. Lenalidomide has begun to be used to treat HCC; however, to the best of our knowledge, its efficacy in patients with lenvatinib-resistant HCC remains to be reported on in the literature. The present case report, to the best of our knowledge, describes the first case in the literature of a patient with lenvatinib-resistant aHCC who achieved a partial response after the treatment regimen was switched to lenalidomide. The present case report provides a promising novel route for the treatment of lenvatinib-resistant HCC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11273340 | PMC |
| http://dx.doi.org/10.3892/etm.2024.12642 | DOI Listing |
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