AI Article Synopsis
- The study explores the use of essential oils, like cinnamaldehyde and carvacrol, as adjuncts to existing antimicrobials to combat methicillin-resistant Staphylococcus aureus (MRSA) and reduce antimicrobial resistance.
- Various tests were conducted to assess the effectiveness of these essential oils, their safety on human cells, and their ability to work in synergy with traditional antimicrobials.
- Findings indicate that essential oils have strong antimicrobial properties, particularly against MRSA, and can enhance the effectiveness of standard treatments, though some components showed cytotoxic effects.
Article Abstract
Using existing adrentimicrobials with essential oil components to prevent antimicrobial resistance is an alternative strategy. This study aimed to evaluate the resistance status, synergistic combinations, and biofilm formation activities of clinical isolates of methicillin-resistant (MRSA), and against antimicrobial agents and cinnamaldehyde, carvacrol, eugenol, limonene and eucalyptol. Antimicrobial activities were evaluated by microdilution, cytotoxicity by XTT, synergy by checkerboard and time-kill, and biofilm inhibition by microplate methods. Cinnamaldehyde and carvacrol showed strong antimicrobial activity. Synergistic effects were observed when using all essential oils with antimicrobials. Only two isolates showed antagonism with cinnamaldehyde and fluconazole. The constituents showed cytotoxic effects in the L929 cell line (except limonene). A time-kill analysis revealed a bacteriostatic effect on and MRSA isolates and a fungicidal effect on isolates. These results are important for further research to improve antimicrobial efficacy or to develop new agents.
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| http://dx.doi.org/10.1080/08927014.2024.2381587 | DOI Listing |
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