AI Article Synopsis
- This study evaluates the effectiveness of frozen section analysis of subareolar tissue in predicting nipple-areola complex (NAC) recurrence after nipple-sparing mastectomy (NSM) for breast cancer.
- Analyzing data from 126 patients, the frozen section showed a high sensitivity and specificity, with a NAC recurrence rate of 4.3% over a follow-up period of around 48 months.
- Atypical ductal hyperplasia (ADH) at the nipple margin was identified as a significant risk factor for recurrence, indicating the need for possible re-excision.
Article Abstract
Purpose: Controversies persist regarding contraindications for nipple-sparing mastectomy (NSM). This study aimed to assess the accuracy of subareolar frozen section analysis and identify risk factors for nipple-areola complex (NAC) recurrence post NSM.
Methods: Consecutive cases of primary invasive breast cancer undergoing NSM at our single center from January 2015 to December 2020 were retrospectively reviewed.
Results: The nipples were retained in 126 patients (127 breasts), and the areola was retained with nipple excision for five breasts. Frozen section analysis demonstrated a sensitivity of 81.8% and specificity of 95.3%. The NAC recurrence rate was 4.3% over a median follow-up period of 48 (30-105) months. An atypical ductal hyperplasia (ADH) at the margin emerged as an independent factor for NAC recurrence in multivariate Cox regression analysis (hazard ratio, 25.464; 95% confidence interval, 1.841-352.145; = 0.016). Kaplan-Meier survival analysis revealed no statistically significant reduction in overall survival rates (log-rank test, = 0.660).
Conclusion: Frozen sections of subareolar tissue are reliable and re-excision may be necessary when ADH is detected at the nipple margin in NSM. The NAC recurrence rate was low, and the outcome was favorable following wide local excision.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377941 | PMC |
| http://dx.doi.org/10.4048/jbc.2024.0077 | DOI Listing |
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