In order to augment the efficacy of the intelligent evaluation model for assessing the suitability of ice and snow tourism, this study refines the model by incorporating the Long Short-Term Memory (LSTM) network within the framework of the Internet of Things (IoT). The investigation commences with an elucidation of the application of IoT technology in environmental detection. After this, an analysis is conducted on the structure of LSTM and its merits in the realm of time series prediction. Ultimately, a novel model for appraising the suitability of ice and snow tourism is formulated. The efficacy of this model is substantiated through empirical experiments. The results of these experiments reveal that the refined model exhibits exceptional performance across diverse climatic conditions, encompassing mild, cold, humid, and arid climates. In regions characterized by mild climates, the predictive accuracy of the refined model progressively ascends from 88% in the initial quarter to 94% in the fourth quarter, surpassing the capabilities of conventional models. Consistently robust performance is demonstrated by the refined model throughout each quarter. In terms of operational efficiency, comparative analysis indicates that the refined model attains a moderate level, manifesting a 30-33 s runtime and maintaining a Central Processing Unit (CPU) usage rate between 40 and 43%. This observation implies that the refined model adeptly balances precision against resource consumption. Consequently, this study holds significance as a scholarly reference for the integration of IoT and LSTM networks in the domain of tourism evaluation.
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http://dx.doi.org/10.1038/s41598-024-68457-w | DOI Listing |
Pharmaceutics
January 2025
Department of Mathematical and Physical Sciences, Catholic University of Temuco, Temuco 4813302, Chile.
: A previous study investigated the in vitro release of methylene blue (MB), a widely used cationic dye in biomedical applications, from nanocellulose/nanoporous silicon (NC/nPSi) composites under conditions simulating body fluids. The results showed that MB release rates varied significantly with the nPSi concentration in the composite, highlighting its potential for controlled drug delivery. To further analyze the relationship between diffusion dynamics and the MB concentration, this study developed a finite element (FE) method to solve Fick's equations governing the drug delivery system.
View Article and Find Full Text PDFPolymers (Basel)
January 2025
Department of Chemistry and Chemical Technology, Manash Kozybayev North Kazakhstan University, Petropavlovsk 150000, Kazakhstan.
The aim of the work was to study the effect of additive concentration on changes in the adhesive and cohesive strength of bitumen. To evaluate the effectiveness of modifiers in the composition of binary and triple bitumen systems in relation to mineral fillers of two grades, the method of determination of the adhesive efficiency and thermodynamic calculations of adhesion and cohesion work were used. The following compounds were used as additives: synthesized from the oil refining waste and (waste sealing liquid).
View Article and Find Full Text PDFPharmaceuticals (Basel)
January 2025
MatTek Corporation, Ashland, MA 01721, USA.
Risk of lung damage from inhaled chemicals or substances has long been assessed using animal models. However, New Approach Methodologies (NAMs) that replace, reduce, and/or refine the use of animals in safety testing such as 2D and 3D cultures are increasingly being used to understand human-relevant toxicity responses and for the assessment of hazard identification. Here we review 2D and 3D lung models in terms of their application for inhalation toxicity assessment.
View Article and Find Full Text PDFPharmaceuticals (Basel)
January 2025
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, 22# Zhongguancun South Avenue, Haidian District, Beijing 100081, China.
Tumors, as intricate ecosystems, comprise oncocytes and the highly dynamic tumor stroma. Tumor stroma, representing the non-cancerous and non-cellular composition of the tumor microenvironment (TME), plays a crucial role in oncogenesis and progression, through its interactions with biological, chemical, and mechanical signals. This review aims to analyze the challenges of stroma mimicry models, and highlight advanced personalized co-culture approaches for recapitulating tumor stroma using patient-derived tumor organoids (PDTOs).
View Article and Find Full Text PDFPharmaceuticals (Basel)
January 2025
Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin 150081, China.
Background/objectives: Septic cardiomyopathy (SCM) is a severe cardiac complication of sepsis, characterized by cardiac dysfunction with limited effective treatments. This study aimed to identify repurposable drugs for SCM by integrated multi-omics and network analyses.
Methods: We generated a mouse model of SCM induced by lipopolysaccharide (LPS) and then obtained comprehensive metabolic and genetic data from SCM mouse hearts using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and RNA sequencing (RNA-seq).
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