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"Applications of Machine Learning in Liposomal Formulation and Development".
Pharm Dev Technol
January 2025
School of Medicine, University of Jordan, Amman 19328, Jordan.
Machine learning (ML) has emerged as a transformative tool in drug delivery, particularly in the design and optimization of liposomal formulations. This review focuses on the intersection of ML and liposomal technology, highlighting how advanced algorithms are accelerating formulation processes, predicting key parameters, and enabling personalized therapies. ML-driven approaches are restructuring formulation development by optimizing liposome size, stability, and encapsulation efficiency while refining drug release profiles.
View Article and Find Full Text PDFPost-marketing safety concerns with lecanemab: a pharmacovigilance study based on the FDA Adverse Event Reporting System database.
Alzheimers Res Ther
January 2025
Department of Pharmacy, Xuanwu Hospital of Capital Medical University, No. 45, Changchun Street, Xicheng District, Beijing, 100053, People's Republic of China.
Background: The safety data of lecanemab in the post-marketing period has yet to be fully investigated in the current literature. We aimed to identify and characterise the safety profile of lecanemab in the post-marketing period.
Methods: We searched and reviewed the reports submitted to the FDA's Adverse Event Reporting System (FAERS).
Solid Lipid Nanoparticles Coated with Glucosylated poly(2-oxazoline)s: A Supramolecular Toolbox Approach.
Biomacromolecules
January 2025
Institute of Macromolecular Chemistry, CAS, Heyrovského nám. 2, Praha 6 162 06, Czech Republic.
Multifunctional polymers are interesting substances for the formulation of drug molecules that cannot be administered in their pure form due to their pharmacokinetic profiles or side effects. Polymer-drug formulations can enhance pharmacological properties or create tissue specificity by encapsulating the drug into nanocontainers, or stabilizing nanoparticles for drug transport. We present the synthesis of multifunctional poly(2-ethyl-2-oxazoline--2-glyco-2-oxazoline)s containing two reactive end groups, and an additional hydrophobic anchor at one end of the molecule.
View Article and Find Full Text PDFMicrobial production of food lipids using the oleaginous yeast Apiotrichum brassicae.
Food Res Int
January 2025
VTT Technical Research Centre of Finland, Tekniikantie 21, 02044 VTT Espoo, Finland. Electronic address:
Oleaginous yeasts offer a promising sustainable alternative for producing edible lipids, potentially replacing animal and unsustainable plant fats and oils. In this study, we screened 11 oleaginous yeast species for their lipid profiles and identified Apiotrichum brassicae as the most promising candidate due to its versatility across different growth media. A.
View Article and Find Full Text PDFEffect of glycoside hydrolase-mediated wheat arabinoxylan hydrolysate on gut microbiota and metabolite profiles.
Carbohydr Polym
March 2025
Center of Food Colloids and Delivery for Functionality, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China; Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China; China Agricultural University-Sichuan Advanced Agricultural & Industrial Institute, Sichuan, Chendu, 610046. Electronic address:
Cereal arabinoxylans (AX) are complex non-digestible polysaccharides and their molecular structural features significantly influence their degradation and metabolic behaviors within the body. This study focuses on investigating the impact of wheat AX hydrolysates produced by different glycoside hydrolases on the gut microbiota during colonic fermentation. Endo-1,4-β-xylanase (XYN) and arabinofuranosidase (ARF) were used to hydrolyze the xylan backbone and remove the arabinose side chains, respectively.
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