AI Article Synopsis
- - Diabetic foot ulcers (DFUs) are increasingly common chronic wounds that present significant challenges in healthcare, particularly due to their complications in the healing process, including issues with blood vessel formation (angiogenesis).
- - The disruption in the balance of certain microRNAs (miRNAs) can negatively impact angiogenesis, making them important factors in the healing of chronic wounds and potentially serving as biomarkers for these wounds.
- - This review focuses on understanding how specific pro- and anti-angiomiRs influence wound healing in diabetic foot ulcers and the potential of using these molecules for therapeutic purposes to promote angiogenesis.
Article Abstract
Diabetic foot ulcers, as one of the chronic wounds, are a serious challenge in the global healthcare system which have shown notable growth in recent years. DFU is associated with impairment in various stages of wound healing, including angiogenesis. Aberrant expression of microRNAs (miRNAs) involved in the disruption of the balance between angiogenic and anti-angiogenic factors, plays a crucial role in angiogenesis dysfunction. Alteration in the expression of angiomiRNAs (angiomiRs) have the potential to function as biomarkers in chronic wounds. Additionally, considering the rising importance of therapeutic RNAs, there is potential for utilizing angiomiRs in wound healing to induce angiogenesis. This review aims to explore angiogenesis in chronic wounds and investigate the mechanisms mediated by pro- and anti-angiomiRs in the context of diabetic foot ulcers.
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| http://dx.doi.org/10.1016/j.pbiomolbio.2024.07.006 | DOI Listing |
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