AI Article Synopsis

  • Livedoid vasculopathy (LV) is a chronic skin condition that leads to painful leg ulcers and results in scarring.
  • A 31-year-old woman underwent diagnosis for recurrent leg ulcers and was confirmed to have LV after extensive testing to rule out other conditions.
  • She experienced significant improvement and complete ulcer resolution over 5 months with a treatment plan that included pentoxifylline, nifedipine, and warfarin, emphasizing the need for thorough diagnosis and collaborative treatment methods.

Article Abstract

Livedoid vasculopathy (LV) is a chronic, recurrent thrombotic vasculopathy characterized by painful ulcerations on the lower extremities, which heal slowly and leave atrophic white scars known as "atrophie blanche." This report presents the case of a 31-year-old woman with a 4-year history of recurrent painful ulcerations on her legs and feet. A skin biopsy revealed findings consistent with LV, and an exhaustive laboratory workup ruled out secondary causes such as thrombophilia, malignancies, autoimmune diseases, and peripheral arterial disease. The patient showed remarkable improvement with a treatment regimen of pentoxifylline, nifedipine, and warfarin, resulting in complete ulcer resolution and sustained remission over 5 months. Our case highlights the importance of a comprehensive diagnostic approach and a multidisciplinary treatment strategy in managing primary LV to achieve remission and prevent recurrence of skin ulcerations.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284771PMC
http://dx.doi.org/10.1177/23247096241266090DOI Listing

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Livedoid vasculopathy (LV) is a rare vascular disorder characterized by excessive thrombosis of cutaneous vasculature, leading to dermal vessel occlusion, skin hypoxia, and ulceration. The nonspecific nature of its clinical manifestations often complicates diagnosis and inadequate oxygenation results in lesions that take longer to heal and are more susceptible to infections and complications. Despite its impact on patient quality of life, LV remains largely undocumented in the literature, making effective management challenging.

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