Background: Coffee beans have a long history of use as traditional medicine by various indigenous people. Recent focus has been given to the health benefits of coffee beans and its bioactive compounds. Research on the bioactivities, applications, and effects of processing methods on coffee beans' phytochemical composition and activities has been conducted extensively. The current review attempts to provide an update on the biological effects of coffee on type 2 diabetes (T2D) and its comorbidities.
Methods: Comprehensive literature search was carried out on peer-reviewed published data on biological activities of coffee on in vitro, in vivo and epidemiological research results published from January 2015 to December 2022, using online databases such as PubMed, Google Scholar and ScienceDirect for our searches.
Results: The main findings were: firstly, coffee may contribute to the prevention of oxidative stress and T2D-related illnesses such as cardiovascular disease, retinopathy, obesity, and metabolic syndrome; secondly, consuming up to 400 mg/day (1-4 cups per day) of coffee is associated with lower risks of T2D; thirdly, caffeine consumed between 0.5 and 4 h before a meal may inhibit acute metabolic rate; and finally, both caffeinated and decaffeinated coffee are associated with reducing the risks of T2D.
Conclusion: Available evidence indicates that long-term consumption of coffee is associated with decreased risk of T2D and its complications as well as decreased body weight. This has been attributed to the consumption of coffee with the abundance of bioactive chemicals.
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http://dx.doi.org/10.1016/j.dsx.2024.103075 | DOI Listing |
Plants (Basel)
January 2025
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
This study investigates the potential synergistic effects of extracts from (turmeric), (Arabica coffee beans), and (chili peppers) in reducing oxidative stress and inflammation, which are associated with metabolic disorders such as obesity, diabetes, and cardiovascular diseases. Using a systematic design of experiment (DoE) optimization approach, an optimal extract ratio of 1:3:4 (turmeric: coffee: chili) was identified. The efficacy of the extract combination was assessed through various antioxidant assays, inhibition of inflammation-related gene expression, and safety testing via the 3-(4,5-dimethylthazolk-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.
View Article and Find Full Text PDFPlants (Basel)
January 2025
Departamento de Química, Universidade Federal de Viçosa, Campus Universitário, Avenida Peter Henry Rolfs, s/n, Viçosa 36570-900, MG, Brazil.
Soxhlet extraction is a method recommended by the Association of Official Analytical Chemists (AOAC) to determine the lipid content in plant samples. Generally, n-hexane (toxicity grade 5) is used as the solvent (≈300 mL; ≈30 g sample) at boiling temperatures (69 °C) for long times (≤16 h) under a chilled water reflux (≈90 L/h), proportionally aggravated by the number of repetitions and samples determined. In this sense, the technique is neither safe nor sustainable for the analyst or the environment.
View Article and Find Full Text PDFPlants (Basel)
January 2025
Laboratory of Precision Agriculture (LAP), Department of Biosystems Engineering, "Luiz de Queiroz" College of Agriculture (ESALQ), University of São Paulo (USP), Piracicaba 13418-900, São Paulo, Brazil.
Coffee yield exhibits plant-level variability; however, due to operational issues, especially in smaller operations, the scouting and management of coffee yields are often hindered. Thus, a cell-size approach at the field level is proposed as a simple and efficient solution to overcome these constraints. This study aimed to present the feasibility of a cell-size approach to characterize spatio-temporal coffee production based on soil and plant attributes and yield (biennial effects) and to assess strategies for enhanced soil fertilization recommendations and economic results.
View Article and Find Full Text PDFFoods
January 2025
Network of Chemistry and Technology/Associated Laboratory for Green Chemistry (REQUIMTE/LAQV), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Coffee pulp, a by-product of wet coffee processing, shows significant potential in the food and health domains, but its real applications remain underexplored. This work investigated the chemical composition and bioactive properties of coffee pulp from São Miguel Island (Azores, Portugal). The studied coffee pulp exhibited high fiber content (52% dw), mostly insoluble; notable mineral levels (10.
View Article and Find Full Text PDFHereditas
January 2025
Health Management Research Center, School of Public Health, Southeast University, 87 Dingjiaqiao Road, Gulou District, Nanjing, 210009, P.R. China.
Objectives: Two-sample MR methods were employed to analyze the impact of smoking and bitter beverage consumption on the risk of osteoporosis and osteoporosis with pathological fractures, in order to assess the causal association.
Methods: Publicly available genome-wide association study summary data were analyzed using MR methods. The exposures investigated were smoking (smoking per day, smoking initiation, and lifetime smoking index) and bitter beverages (coffee, tea, bitter alcoholic beverages, bitter non-alcoholic beverages, and total bitter beverages).
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