Objective: Alloimmunization against red blood cell (RBC) antigen is an important concern in myelodysplastic syndromes (MDSs) patients with chronic transfusion, causing potential risk for hemolytic reaction and limited supply of compatible blood. However, there is little data addressing RBC alloimmunization in this patient cohort among the Chinese population. This study aims to evaluate the incidence, specificity of antibodies, and RBC units transfused before antibody formation and its significance in a population of patients consistently receiving RhD-matched RBC units.
Methods: We retrospectively reviewed the transfusion and clinical information of all transfused patients with MDS enrolled in our hospital from 2012 to 2022. The cumulative incidence of alloimmunization was analyzed by a Kaplan-Meier plot. Alloimmunization incidence was compared based on different transfused RBC units using the log-rank test.
Results: A total of 103 patients with MDS were included in this study; alloantibody formed in 8 (7.8%) patients. Before reaching 32 RBC units, 87.5% of the alloimmunized patients had developed their alloantibodies. All but 1 of the alloantibodies developed were antibodies to Rh antigens. The RBC transfusion intensity and frequency were significantly higher following alloimmunization in the alloimmunized patients (P = .008, P = .008, respectively).
Conclusion: The antibodies detected mostly involve the Rh system among MDS patients in China. The alloimmunization tended to occur early prior to reaching 32 RBC units in patients with MDS. Rh antigen matching should be considered early in the patient's transfusion history and completed before receiving 32 RBC units.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/labmed/lmae056 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Is it possible to predict severe postpartum hemorrhage and the need for massive transfusion in placenta previa cases?
Ginekol Pol
March 2025
Department of Obstetrics and Gynecology, Okan University School of Medicine, Istanbul, Türkiye.
Objectives: The aim was to construct a reliable working model for patients with placenta previa (PP) that aids in the prediction of postpartum bleeding potential with data from antenatal imaging studies using both ultrasound (US) and magnetic resonance imaging (MRI).
Material And Methods: Forty-three patients with PP were evaluated initially with the US and then by 3-Tesla MRI. The Placenta Accreata Index (PAI) was used during the US evaluation in order to define the risks.
Surgical procedure and retrospective comparative series of Microport's AnteriorPath vs. AMIS in total hip arthroplasty. Preliminary findings from a single institution.
Turk J Surg
March 2025
Department of Orthopedics and Trauma Surgery, University of Essen, St. Josef Hospital, Essen-Werden, Germany.
Objective: In recent years, the paradigm of surgical approaches for total hip arthroplasty (THA) has evolved, with portal-assisted techniques emerging as a promising avenue for increasing precision and minimizing invasiveness. The purpose of this study was to compare early experience with the Microport anterior percutaneously assisted total hip arthroplasty (MAP) system, with the established AMIS direct anterior approach (DAA).
Material And Methods: A retrospective chart analysis was performed on 200 consecutive patients who underwent DAA or MAP at our institution in 2022.
Minimisation of blood sampling losses in preterm neonates: a systematic review and meta-analysis.
Arch Dis Child Fetal Neonatal Ed
March 2025
Neonatal Directorate, King Edward Memorial Hospital for Women, Subiaco, Western Australia, Australia.
Objective: To evaluate the effect of minimising blood sampling losses on red blood cell (RBC) transfusion-related outcomes in preterm infants <37 weeks' gestation.
Study Design: We searched PubMed, Embase, Web of Science and Google Scholar from inception to October 2024 for studies that evaluated sampling stewardship practices (SSP) in preterm infants during initial hospitalisation. Two authors independently screened articles that evaluated one or more sampling approaches to minimise blood loss or non-invasive methods to avoid sampling losses.
Efficient Quality Improvement through the monitoring of Key Performance Indicators in the Quality Management Review of a Blood Establishment (BE).
Transfus Clin Biol
February 2025
Transfusion Medicine Department, General Oncology Hospital of Athens "Agios Savvas", Greece.
Efficient quality improvement in Blood Establishments (BE) relies on monitoring Key Performance Indicators (KPIs) within the Quality Management Review (QMR). KPIs serve as objective measures to identify system weaknesses and promote continuous quality improvement. The QMR integrates KPI data with inputs from various sources like non-conformities and audit reports, facilitating informed decision-making for improvement initiatives.
View Article and Find Full Text PDFTwo Nonmyeloablative HLA-Matched Related Donor Allogeneic Hematopoietic Cell Transplantation Regimens in Patients with Severe Sickle Cell Disease.
Transplant Cell Ther
February 2025
Cellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Nonmyeloablative (NMA) conditioning is being used increasingly with success in matched related donor (MRD) and alternative donor allogeneic hematopoietic cell transplantation (allo-HCT) in individuals with sickle cell disease (SCD). Advantages include decrease toxicity and applicability in patients otherwise unable to tolerate conditioning regimens due to end-organ damage or age. We aimed to add to published data outcomes of two similar NMA conditioning protocols, termed Protocol 1 (ClinicalTrials.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!