AI Article Synopsis
- The cerebral cortex plays a more active role in Parkinson's disease than previously thought, impacting motor symptoms beyond just receiving signals from the basal ganglia.
- Recent research highlights significant changes in the frontal cortical motor areas related to neuropathology, plasticity, and neurotransmission, indicating complex involvement in the disease.
- The review also explores how understanding these cortical changes might open up new avenues for neuromodulation therapies to treat Parkinson's disease.
Article Abstract
The cerebral cortex has long been thought to be involved in the pathophysiology of motor symptoms of Parkinson's disease. The impaired cortical function is believed to be a direct and immediate effect of pathologically patterned basal ganglia output, mediated to the cerebral cortex by way of the ventral motor thalamus. However, recent studies in humans with Parkinson's disease and in animal models of the disease have provided strong evidence suggesting that the involvement of the cerebral cortex is much broader than merely serving as a passive conduit for subcortical disturbances. In the present review, we discuss Parkinson's disease-related changes in frontal cortical motor regions, focusing on neuropathology, plasticity, changes in neurotransmission, and altered network interactions. We will also examine recent studies exploring the cortical circuits as potential targets for neuromodulation to treat Parkinson's disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11281850 | PMC |
| http://dx.doi.org/10.1093/cercor/bhae294 | DOI Listing |
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