AI Article Synopsis
- Detection methods are being developed to stop the spread of certain pig viruses associated with xenotransplantation, where pig organs are transplanted to humans.
- Researchers screened 10 pigs from German slaughterhouses for 11 types of viruses, including porcine cytomegalovirus and others related to xenotransplantation, using PCR and immunological tests.
- The study found five viruses consistently present in all pigs, highlighting how some pigs were either actively infected or latently infected, which is crucial for understanding viral safety in xenotransplantation.
Article Abstract
Detection methods have been developed to prevent transmission of zoonotic or xenozoonotic porcine viruses after transplantation of pig organs or cells to the recipient (xenotransplantation). Eleven xenotransplantation-relevant viruses, including porcine cytomegalovirus, porcine roseolovirus (PCMV/PRV), porcine lymphotropic herpesviruses -1, -2, -3 (PLHV-1, 2, 3), porcine parvovirus (PPV), porcine circovirus 2, 3, 4 (PCV2, 3, 4), hepatitis E virus genotype 3 (HEV3), porcine endogenous retrovirus-C (PERV-C), and recombinant PERV-A/C have been selected. In the past, several pig breeds, minipigs, and genetically modified pigs generated for xenotransplantation had been analyzed using these methods. Here, spleen, liver, and blood samples from 10 German slaughterhouse pigs were screened using both PCR-based and immunological assays. Five viruses: PCMV/PRV, PLHV-1, PLHV-3, and PERV-C, were found in all animals, and PCV3 in one animal. Some animals were latently infected with PCMV/PRV, as only virus-specific antibodies were detected. Others were also PCR positive in the spleen and/or liver, indicative of an ongoing infection. These results provide important information on the viruses that infect German slaughterhouse pigs, and together with the results of previous studies, they reveal that the methods and test strategies efficiently work under field conditions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11281539 | PMC |
| http://dx.doi.org/10.3390/v16071119 | DOI Listing |
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