Molecularly Imprinted Polymeric Nanoparticles as Drug Delivery System for Tenofovir, an Acyclic Nucleoside Phosphonate Antiviral.

Pharmaceutics

Institute of Organic and Analytical Chemistry (ICOA UMR 7311), University of Orleans, Centre National de la Recherche Scientifique, F-45067 Orléans, France.

Published: July 2024

A molecularly imprinted polymer of Tenofovir (1), an FDA-approved acyclic nucleoside phosphonate with antiviral activity, was synthesized using a non-covalent approach. A pre-polymerization complex was formed between (1) and DMAEMA and in-house synthetic -[(2-methacryloyloxy)ethyl] thymine, with EGDMA as a cross-linker in an MeCN/HO (9:1, 1:1) mixture as a porogen, giving an imprinting factor (IF) of 5.5 at 2.10 mol/L. Binding parameters were determined by the Freundlich-Langmuir model, Q and K, and well as the particle morphology for MIP and NIP. Finally, the release profiles, for MIP and NIP, were obtained at 25 °C and 37 °C, which is body temperature, in a phosphate buffer saline, pH 7.4, mimicking the blood pH value, to determine the potential sustained release of our polymeric materials.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11280436PMC
http://dx.doi.org/10.3390/pharmaceutics16070965DOI Listing

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