AI Article Synopsis
- Colorectal cancer (CRC) is a prevalent cancer globally, and there's growing research on the link between CRC and intestinal microbiota.
- Selenium compounds are of interest as potential anticancer treatments due to their low side effects.
- A study showed that selenomethionine is more effective than sodium selenite in reducing intestinal microbiota diversity in CRC-affected mice, helping to restore healthier microbial levels.
Article Abstract
Colorectal cancer (CRC) is the third most common cancer worldwide. The role of intestinal microbiota in carcinogenesis has also become an important research topic, and CRC is closely related to the intestinal microbiota. Selenium-containing compounds have attracted more attention as anticancer drugs as they can have minimal side effects. The purpose of this study was to determine and compare the effect of sodium selenite and selenomethionine on the microbial communities of nude mice with CRC. A CRC ectopic tumorigenesis model was established by subcutaneously injecting HCT116 cells into nude mice. The mice were then intraperitoneally injected with sodium selenite and selenomethionine for 24 days to regulate their intestinal microbiota. Compared with sodium selenite, selenomethionine resulted in a greater reduction in the richness and diversity of intestinal microbiota in nude mice with CRC, and the richness and diversity were closer to healthy levels. Selenomethionine also regulated a wider variety of flora. Additionally, sodium selenite and selenomethionine produced different microorganisms, changed function and metabolic pathways in the intestinal microbiota. Both sodium selenite and selenomethionine have certain effects on restoring the intestinal microbial diversity in nude mice with CRC, and the effect of selenomethionine is better than that of sodium selenite.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11279152 | PMC |
| http://dx.doi.org/10.3390/microorganisms12071336 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Date seeds polysaccharides as novel capping agents for selenium nanoparticles: Synthesis, characterization, stability, biological activities, and gut microbiota modulation.
Food Chem
January 2025
Department of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University (UAEU), PO Box 15551, Al-Ain, United Arab Emirates. Electronic address:
Date seed polysaccharides were utilized to synthesize selenium nanoparticles (MPS-NP) through a redox reaction involving sodium selenite and ascorbic acid. Characterization of MPS-NP showed a uniform, amorphous, spherical shape with a particle size of 89.2 nm, remaining stable for 42 days.
View Article and Find Full Text PDFSodium selenite enhanced the selenium content in black soldier fly.
Sci Rep
January 2025
College of Animal Science, Anhui Science and Technology University, Bengbu, 233100, People's Republic of China.
This study focuses on the effects of different levels of sodium selenite on the growth, selenium content, and antioxidant capacity of black soldier fly (Hermetia illucens). The experiment used different doses of sodium selenite for treatment, including a basic diet with no supplements (control) and diets supplemented with 10 mg/kg (Se10), 20 mg/kg (Se20), 30 mg/kg (Se30), and 40 mg/kg (Se40) sodium selenite, and results show that sodium selenite supplementation significantly increases selenium content and improves selenium utilization and antioxidant capacity (P < 0.05).
View Article and Find Full Text PDFBioremediation Potential of PM1 in Sodium Selenite-Contaminated Soil and Its Impact on Microbial Community Assembly.
Microorganisms
November 2024
Hubei Key Laboratory of Biological Resources Protection and Utilization, Hubei Minzu University, Enshi 445000, China.
Soil microbial communities are particularly sensitive to selenium contamination, which has seriously affected the stability of soil ecological environment and function. In this study, we applied high-throughput 16S rRNA gene sequencing to examine the effects of low and high doses of sodium selenite and the selenite-degrading bacterium, PM1, on soil bacterial community composition, diversity, and assembly processes under controlled laboratory conditions. Our results indicated that sodium selenite and strain PM1 were key predictors of bacterial community structure in selenium-contaminated soils.
View Article and Find Full Text PDFAmikacin-loaded selenium nanoparticles improved antibacterial and antibiofilm activity of amikacin against bovine mastitis-causing .
Heliyon
January 2025
Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran.
Background: Antibiotic resistance in various microorganisms has become one of the most serious health problems worldwide. The use of nanoparticles in combination with conventional antibiotics is one of the recent efforts to overcome these challenges. This study aims to synthesize and evaluate the possibility of using amikacin-loaded selenium nanoparticles as antibacterial agent against multidrug-resistant , that causes bovine mastitis.
View Article and Find Full Text PDFPreparation, characterization, and anticancer effect of Capsaicin-functionalized selenium nanoparticles.
Front Nutr
December 2024
School of Public Health, Guangzhou Medical University, Guangzhou, China.
Introduction: Selenium nanoparticles (SeNPs) are recently emerging as promising anticancer agents because of their high bioavailability, low toxicity and remarkable anticancer activities. However, the application of SeNPs in anticancer has been limited due to instability. Herein, Capsaicin (Cap), a natural active compound found in chili peppers with favorable anticancer activity, was modified with SeNPs to prepare Cap-decorated SeNPs (Cap@SeNPs), and the antiproliferative effect and mechanism of Cap@SeNPs in HepG2 were investigated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!