AI Article Synopsis
- A study of 1381 HIV-positive Veterans from 2016 to 2023 found that 20.6% met the clinical criteria for lymphogranuloma venereum (LGV), with 63% classified as probable cases.
- Of the identified LGV cases, 81% presented with proctitis, and key risk factors included male birth sex and being a man who has sex with men.
- Only 43.7% of the LGV cases received standard treatment, suggesting that LGV may be underestimated and inadequately treated in this population.
Article Abstract
We applied lymphogranuloma venereum (LGV) clinical case criteria to a cohort of 1381 Veterans positive for HIV and (CT) from 2016 from 2023 and analyzed variables to ascertain risk factors for LGV and factors associated with the use of standard treatment regimens. In total, 284/1381 (20.6%) met the criteria for LGV. A total of 179/284 (63%) were probable cases, and 105/284 (37%) were possible cases (those meeting clinical criteria but with concurrent sexually transmitted infections (STI) associated with LGV-like symptoms). None had confirmatory CT L1-L3 testing. A total of 230 LGV cases (81%) presented with proctitis, 71 (25%) with ulcers, and 57 (20.1%) with lymphadenopathy. In total, 66 (23.2%) patients had >1 symptom of LGV. A total of 43 (15%) LGV cases were hospitalized. Primary risk factors for LGV were male birth sex ( = 0.004), men who have sex with men ( < 0.001), and the presence of STIs other than gonorrhea or syphilis ( = 0.011). In total, 124/284 (43.7%) LGV cases received standard recommended treatment regimens. Probable cases were more likely to receive standard treatment than possible cases ( = 0.003). We report that 20.6% of CT cases met clinical criteria for LGV among HIV-infected Veterans and that less than half of cases received recommended treatment regimens, indicating that LGV is likely underestimated and inadequately treated among this US population.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11278903 | PMC |
| http://dx.doi.org/10.3390/microorganisms12071327 | DOI Listing |
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