Background: Kawasaki disease (KD) is a syndrome primarily affecting young children, typically under the age of five, and is characterized by the development of acute vasculitis. Through extensive research conducted on both murine and human subjects, it has been demonstrated that heightened levels of reactive oxygen species (ROS) play a pivotal role in the development of KD, especial coronary artery lesions (CALs). Hydrogen gas exhibits potent antioxidant properties that effectively regulate ROS production and the inflammatory response.
Methods: We used cell wall extract (LCWE)-induced vasculitis in mice as an animal model of KD and treated the mice with hydrogen gas inhalation.
Results: We observed significant dilatation and higher Z scores in the left coronary artery (LCA) in D21 and D28 in mice after LCWE treatment compared to the control group ( < 0.001) and a significant resolution of LCA diameters ( < 0.01) and Z scores ( < 0.01) after treatment with inhaled hydrogen gas. We further demonstrated that serum IL-6 expression was higher in mice after LCWE treatment ( < 0.01) and IL-6 significantly decreased after inhaled hydrogen gas therapy ( < 0.001).
Conclusion: According to our literature review, this is the first report where hydrogen gas inhalation has been demonstrated to be effective for the treatment of coronary artery dilatation in a KD murine model.
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http://dx.doi.org/10.3390/life14070796 | DOI Listing |
Environ Pollut
December 2024
School of Public Administration, Hohai University, Nanjing 211000, China; Observation Research Station of Land Ecology and Land Use in the Yangtze River Delta, Ministry of Natural Resources, Nanjing 210009, China. Electronic address:
Due to the rapid increase in industrial and urban areas, environmental pollution is increasing worldwide, which is causing unwanted changes in air, water, and soil at biological, physical, as well as chemical levels that ultimately causing the negative effects in living things because of toxic level of chromium (Cr). However, nanotechnology is capturing great interest worldwide due to their stirring applications in various fields. For this purpose, a pot experiment was conducted to examine plant growth and exo-physiology in rice (Oryza sativa L.
View Article and Find Full Text PDFJ Org Chem
December 2024
Department of Chemistry, Indian Institute of Science Education and Research (IISER) Tirupati, Tirupati 517619, India.
The development of efficient and robust catalytic systems based on earth-abundant transition metals for fundamentally new transformations is crucial for sustainable chemical synthesis. Herein, an effective and selective Ni-catalyzed dehydrogenative coupling of alcohols with hydrazines with the liberation of ammonia gas is reported. Although several methods were documented for the -alkylation reaction, the present strategy is conceptually novel, and the reaction proceeds through a pathway involving N-N bond cleavage of phenylhydrazine followed by hydrogen autotransfer.
View Article and Find Full Text PDFJ Org Chem
December 2024
College of New Energy, State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao 266580, P. R. China.
The photocatalytic dearomative 1,4-hydroboration of naphthalenes with an N-heterocyclic carbene borane (NHC-BH) complex was reported herein with controllable regioselectivity and chemoselectivity. This protocol yielded a wide range of naphthalene derivatives bearing various functional groups, notably bioactive compounds. Hydroboration occurred through the cooperation of photoredox and hydrogen atom transfer via boryl radical addition to naphthalene and further selective protonation.
View Article and Find Full Text PDFInorg Chem
December 2024
Centre for Hydrogenergy, College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, PR China.
Defect engineering in SrTiO crystals plays a pivotal role in achieving efficient overall solar water splitting, as evidenced by the influence of Al ions. However, the uneven structural relaxation caused by Al ions has been overlooked, significantly affecting the defect state and catalytic activity. When an AlO crucible is used, optimizing this defect engineering presents a significant challenge.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China. Electronic address:
The emergence of treatment approaches that integrate conventional phototherapy with additional adjuvant treatments has garnered considerable interest. In this study, we proposed a complex utilizing Fe and polydopamine as a carrier, co-loaded with the nitric oxide initiator L-arginine (L-Arg) and the photosensitizer indocyanine green (ICG), as a potential strategy for the "photothermal/photodynamic/Chemodynamic/nitric oxide gas therapy" of osteosarcoma. Nanoparticles have the ability to undergo degradation within the mildly acidic conditions present in the tumor microenvironment.
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