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Cytomegalovirus in Adenoma and Carcinoma Lesions: Detecting Mono-Infection and Co-Infection in Salivary Glands. | LitMetric

AI Article Synopsis

  • * Among 67 analyzed samples, 50.7% were mucocele, 40.3% pleomorphic adenoma, and 8.9% mucoepidermoid carcinoma, with significant co-infections found particularly in pleomorphic adenoma cases.
  • * Findings indicate a high prevalence of HCMV in salivary gland lesions, suggesting it may play a role in their development, though the absence of polyomaviruses like BKV and JCV does not dismiss their potential involvement in specific lesions.

Article Abstract

Salivary glands' neoplasms are hard to diagnose and present a complex etiology. However, several viruses have been detected in these neoplasms, such as HCMV, which can play a role in certain cancers through oncomodulation. The co-infections between HCMV with betaherpesviruses (HHV-6 and HHV-7) and polyomaviruses (JCV and BKV) has been investigated. The aim of the current study is to describe the frequency of HCMV and co-infections in patients presenting neoplastic and non-neoplastic lesions, including in the salivary gland. Multiplex quantitative polymerase chain reaction was used for betaherpesvirus and polyomavirus quantification purposes after DNA extraction. In total, 50.7% of the 67 analyzed samples were mucocele, 40.3% were adenoma pleomorphic, and 8.9% were mucoepidermoid carcinoma. Overall, 20.9% of samples presented triple-infections with HCMV/HHV-6/HHV-7, whereas 9.0% were co-infections with HCMV/HHV-6 and HCMV/HHV-7. The largest number of co-infections was detected in pleomorphic adenoma cases. All samples tested negative for polyomaviruses, such as BKV and JCV. It was possible to conclude that HCMV can be abundant in salivary gland lesions. A high viral load can be useful to help better understand the etiological role played by viruses in these lesions. A lack of JCV and BKV in the samples analyzed herein does not rule out the involvement of these viruses in one or more salivary gland lesion subtypes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11276870PMC
http://dx.doi.org/10.3390/ijms25147502DOI Listing

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