AI Article Synopsis
- Celiac disease (CD) is an autoimmune disorder triggered by gluten sensitivity, previously thought to only affect white Europeans, but now recognized in various racial groups including South Asians and Africans.
- Recent research focused on genetic variations LPP rs1464510 and ZMIZ1 rs1250552 in the Punjabi Pakistani population, revealing significant associations with CD risk.
- Findings indicated that the LPP rs1464510 A allele reduces CD risk by approximately 52%, while having the C allele increases risk by about 2.6 times; similarly, the AG genotype of rs1250552 decreases risk by 73%.
Article Abstract
Celiac disease (CD) is a complicated autoimmune disease that is caused by gluten sensitivity. It was commonly believed that CD only affected white Europeans, but recent findings show that it is also prevailing in some other racial groups, like South Asians, Caucasians, Africans, and Arabs. Genetics plays a profound role in increasing the risk of developing CD. Genetic Variations in non- genes such as , , , and many more influence the risk of CD in various populations. This study aimed to explore the association between LPP rs1464510 and ZMIZ1 rs1250552 and CD in the Punjabi Pakistani population. For this, a total of 70 human subjects were selected and divided into healthy controls and patients. Genotyping was performed using an in-house-developed tetra-amplification refractory mutation system polymerase chain reaction. Statistical analysis revealed a significant association between LPP rs1464510 (χ = 4.421, = 0.035) and rs1250552 (χ2 = 3.867, = 0.049) and CD. Multinomial regression analysis showed that LPP rs1464510 A allele reduces the risk of CD by ~52% (OR 0.48, CI: 0.24-0.96, 0.037), while C allele-carrying subjects are at ~2.6 fold increased risk of CD (OR 3.65, CI: 1.25-10.63, 0.017). Similarly, the rs1250552 AG genotype significantly reduces the risk of CD by 73% (OR 0.26, CI: 0.077-0.867, = 0.028). In summary, Genetic Variations in the LPP and genes influence the risk of CD in Punjabi Pakistani subjects. LPP rs1464510 A allele and AG genotype play a protective role and reduce the risk of CD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11275600 | PMC |
| http://dx.doi.org/10.3390/genes15070852 | DOI Listing |
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Article Synopsis
- Celiac disease (CD) is an autoimmune disorder triggered by gluten sensitivity, previously thought to only affect white Europeans, but now recognized in various racial groups including South Asians and Africans.
- Recent research focused on genetic variations LPP rs1464510 and ZMIZ1 rs1250552 in the Punjabi Pakistani population, revealing significant associations with CD risk.
- Findings indicated that the LPP rs1464510 A allele reduces CD risk by approximately 52%, while having the C allele increases risk by about 2.6 times; similarly, the AG genotype of rs1250552 decreases risk by 73%.
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