Red blood cell (RBC) storage solutions have evolved significantly over the past decades to optimize the preservation of cell viability and functionality during hypothermic storage. This comprehensive review provides an in-depth analysis of the effects of various storage solutions and conditions on critical RBC parameters during refrigerated preservation. A wide range of solutions, from basic formulations such as phosphate-buffered saline (PBS), to advanced additive solutions (ASs), like AS-7 and phosphate, adenine, glucose, guanosine, saline, and mannitol (PAGGSM), are systematically compared in terms of their ability to maintain key indicators of RBC integrity, including adenosine triphosphate (ATP) levels, morphology, and hemolysis. Optimal RBC storage requires a delicate balance of pH buffering, metabolic support, oxidative damage prevention, and osmotic regulation. While the latest alkaline solutions enable up to 8 weeks of storage, some degree of metabolic and morphological deterioration remains inevitable. The impacts of critical storage conditions, such as the holding temperature, oxygenation, anticoagulants, irradiation, and processing methods, on the accumulation of storage lesions are also thoroughly investigated. Personalized RBC storage solutions, tailored to individual donor characteristics, represent a promising avenue for minimizing storage lesions and enhancing transfusion outcomes. Further research integrating omics profiling with customized preservation media is necessary to maximize post-transfusion RBC survival and functions. The continued optimization of RBC storage practices will not only enhance transfusion efficacy but also enable blood banking to better meet evolving clinical needs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11274915 | PMC |
| http://dx.doi.org/10.3390/biom14070813 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Load-Shifting Strategies for Cost-Effective Emission Reductions at Wastewater Facilities.
Environ Sci Technol
January 2025
Department of Civil and Environmental Engineering, Stanford University, 473 Via Ortega, Stanford, California 94305, United States.
Significant hourly variation in the carbon intensity of electricity supplied to wastewater facilities introduces an opportunity to lower emissions by shifting the timing of their energy demand. This shift could be accomplished by storing wastewater, biogas from sludge digestion, or electricity from on-site biogas generation. However, the life cycle emissions and cost implications of these options are not clear.
View Article and Find Full Text PDFExogenous diethyl aminoethyl hexanoate alleviates the damage caused by low-temperature stress in Phaseolus vulgaris L. seedlings through photosynthetic and antioxidant systems.
BMC Plant Biol
January 2025
College of Horticulture, Sichuan Agricultural University, Chengdu, 611130, China.
Background: Phaseolus vulgaris is a warm-season crop sensitive to low temperatures, which can adversely affect its growth, yield, and market value. Exogenous growth regulators, such as diethyl aminoethyl hexanoate (DA-6), have shown potential in alleviating stress caused by adverse environmental conditions. However, the effects that DA-6 has on P.
View Article and Find Full Text PDFElectrochemical approaches for CO point source, direct air, and seawater capture: identifying opportunities and synergies.
Environ Sci Pollut Res Int
January 2025
Institute for Integrated Energy Systems at University of Victoria (IESVic), Department of Mechanical Engineering, University of Victoria, Victoria, BC, V8P 5C2, Canada.
The world is increasingly facing the direct effects of climate change triggering warnings of a crisis for the healthy existence of humankind. The dominant driver of the climate emergency is the historical and continued accumulation of atmospheric CO altering net radiative forcing on the planet. To address this global issue, understanding the core chemistry of CO manipulation in the atmosphere and proximally in the oceans is crucial, to offer a direct partial solution for emissions handling through negative emissions technologies.
View Article and Find Full Text PDFTannin additions decrease the concentration of malodorous volatile sulfur compounds in wine-like model solutions and wine.
Food Chem
January 2025
Departamento de Horticultura, Facultad de Ciencias Agrarias, Universidad de Talca, 2 Norte 685, Talca, Chile.
Hydrogen sulfide (HS), methanethiol (MeSH) and ethanethiol (EtSH) are volatile sulfur compounds (VSCs) produced during winemaking and are associated with negative 'reductive' aromas in wine. Anecdotal evidence suggests that oenological tannins may be used to remediate the 'reductive' character of wines, yet little scientific evidence or explanation supporting this observation has been published. In this study, it was found that the addition of oenological tannins significantly decreased HS, MeSH, and EtSH in model wine by up to 92 %, 90 % and 86 %, respectively, after two weeks of storage.
View Article and Find Full Text PDFTo add or to remove? The role of working memory updating in preschool children's non-symbolic arithmetic abilities between addition and subtraction.
J Exp Child Psychol
January 2025
Division of Social Science, The Hong Kong University of Science and Technology, Kowloon, Hong Kong SAR, China. Electronic address:
Early computational capacity sets the foundation for mathematical learning. Preschool children have been shown to perform both non-symbolic addition and subtraction problems. However, it is still unknown how different operations affect the representational precision of the non-symbolic arithmetic solutions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!