AI Article Synopsis

  • This study presents a bile duct stent created using indirect 3D printing technology, focusing on four synthesized biodegradable materials from lactic and glycolic acid.
  • The degradation tests showed significant weight loss in these materials over four weeks, with PLGA (50:50) losing the most weight, indicating suitable degradation properties for medical applications.
  • A successful prototype of the stent was manufactured and tested for mechanical properties and biocompatibility, demonstrating promising potential for future use in medical settings, particularly in treating bile duct issues.

Article Abstract

This study proposes a bile duct stent based on indirect 3D printing technology. Four ratio materials were synthesized from lactic acid (LA) and glycolide (GA) monomers by melt polymerization: PLA, PLGA (70:30), PLGA (50:50), and PLGA (30:70). The four kinds of material powders were preliminarily degraded, and the appearance was observed with an optical microscope (OM) and a camera. The weight and appearance of the four materials changed significantly after four weeks of degradation, which met the conditions for materials to be degraded within 4-6 weeks. Among them, PLGA (50:50) lost the most-the weight dropped to 13.4%. A stent with an outer diameter of 10 mm and an inner diameter of 8 mm was successfully manufactured by indirect 3D printing technology, demonstrating the potential of our research. Then, the degradation experiment was carried out on a cylindrical stent with a diameter of 6 mm and a height of 3 mm. The weight loss of the sample was less than that of the powder degradation, and the weight loss of PLGA (50:50) was the largest-the weight dropped to 79.6%. The nano-indenter system measured the mechanical properties of materials. Finally, human liver cancer cells Hep-3B were used to conduct in vitro cytotoxicity tests on the scaffolds to test the biocompatibility of the materials. A bile duct stent meeting commercial size requirements has been developed, instilling confidence in the potential of our research for future medical applications.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11273755PMC
http://dx.doi.org/10.3390/bioengineering11070731DOI Listing

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