AI Article Synopsis
- Gliomas are diverse tumors, and accurately identifying aggressive areas and borders is crucial for diagnosis and treatment; this study explored the use of [F]-FACBC PET for better glioma tissue classification.
- The research involved analyzing pre-surgical [F]-FACBC PET/MR images and comparing their effectiveness with histomolecular results and conventional MRIs through biopsy samples from 17 patients with various glioma grades.
- Findings indicated that [F]-FACBC PET outperformed conventional MRI in sensitivity and specificity for tumor classification, revealing larger tumor volumes in glioblastoma patients and showing potential for improved diagnostic accuracy when used alongside traditional MRI methods.
Article Abstract
Background: Gliomas have a heterogeneous nature, and identifying the most aggressive parts of the tumor and defining tumor borders are important for histomolecular diagnosis, surgical resection, and radiation therapy planning. This study evaluated [F]-FACBC PET for glioma tissue classification.
Methods: Pre-surgical [F]-FACBC PET/MR images were used during surgery and image-localized biopsy sampling in patients with high- and low-grade glioma. TBR was compared to histomolecular results to determine optimal threshold values, sensitivity, specificity, and AUC values for the classification of tumor tissue. Additionally, PET volumes were determined in patients with glioblastoma based on the optimal threshold. [F]-FACBC PET volumes and diagnostic accuracy were compared to ce-T1 MRI. In total, 48 biopsies from 17 patients were analyzed.
Results: [F]-FACBC had low uptake in non-glioblastoma tumors, but overall higher sensitivity and specificity for the classification of tumor tissue (0.63 and 0.57) than ce-T1 MRI (0.24 and 0.43). Additionally, [F]-FACBC TBR was an excellent classifier for IDH1-wildtype tumor tissue (AUC: 0.83, 95% CI: 0.71-0.96). In glioblastoma patients, PET tumor volumes were on average eight times larger than ce-T1 MRI volumes and included 87.5% of tumor-positive biopsies compared to 31.5% for ce-T1 MRI.
Conclusion: The addition of [F]-FACBC PET to conventional MRI could improve tumor classification and volume delineation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11275162 | PMC |
| http://dx.doi.org/10.3390/cancers16142581 | DOI Listing |
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