A novel electrochemical sensor for detection of luteolin in food based on 3D networked electrically interconnected SiO@GO/MXene composite.

Luteolin (Lu), a compound with various biochemical and pharmacological activities beneficial to human health, has attracted researchers' attention. This study proposes an efficient and scalable method using ultrasound to intercalate graphene oxide (GO)-coated silica spheres (SiO) into MXenes, resulting in a 3D conductive interconnected structural composite material. Characterization of the composite material was conducted using SEM, TEM, XRD, XPS, and Raman spectroscopy. MXenes exhibit excellent electrical conductivity, and the SiO@GO surface with abundant hydroxyl and silanol groups provides high-binding active sites that facilitate Lu molecule enrichment. The formation of the 3D conductive interconnected structural composites enhances charge transport, significantly improving sensor sensitivity. Consequently, the sensor demonstrates excellent detection capabilities (detection range 0.03-7000 nM, detection limit 12 pM). Furthermore, the sensor can be applied to quantitative determination of Lu in real samples, including chrysanthemums, Jiaduobao, honeysuckle, purple perilla, and peanut shells, achieving recoveries between 98.2 and 104.7%.