AI Article Synopsis
- Ageing and fertility are connected, with germline loss enhancing lifespan in organisms, known as gonadal longevity.
- Researchers studied the interaction between germline stem cells (GSCs) and distal tip cells (DTCs) in C. elegans to understand the longevity signals from the gonad.
- Findings showed that germline removal disrupts cell adhesions, alters DTC gene expression via specific transcription factors, and identifies the TGF-β ligand tig-2 as a key cytokine in mediating longevity signaling throughout the body.
Article Abstract
Ageing and fertility are intertwined. Germline loss extends the lifespan in various organisms, termed gonadal longevity. However, the original longevity signal from the somatic gonad remains poorly understood. Here, we focused on the interaction between germline stem cells (GSCs) and their niche, the distal tip cells (DTCs), to explore the barely known longevity signal from the somatic gonad in C. elegans. We found that removing germline disrupts the cell adhesions between GSC and DTC, causing a significant transcriptomic change in DTC through hmp-2/β-catenin and two GATA transcription factors, elt-3 and pqm-1 in this niche cell. Inhibiting elt-3 and pqm-1 in DTC suppresses gonadal longevity. Moreover, we further identified the TGF-β ligand, tig-2, as the cytokine from DTC upon the loss of germline, which evokes the downstream gonadal longevity signalling throughout the body. Our findings thus reveal the source of the longevity signalling in response to germline removal, highlighting the stem cell niche as a critical signalling hub in ageing.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11405865 | PMC |
| http://dx.doi.org/10.1038/s44318-024-00185-3 | DOI Listing |
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