AI Article Synopsis
- Cancer is a significant health issue globally, with millions dying each year, and cisplatin, a common chemotherapy drug, has considerable side effects.
- The study explored the effects of Ganoderma lucidum, a traditional Chinese medicine, on reducing the toxicity caused by cisplatin in both cell cultures and mice.
- Results showed that G. lucidum effectively reduced cisplatin-induced damage in cells and mice, likely due to its antioxidant properties, suggesting it could help lessen the negative effects of cisplatin treatment.
Article Abstract
Background/aim: Cancer remains a major global health challenge, with an estimated 10 million cancer-related deaths in 2020, hindering efforts to extend life expectancy. Cisplatin, an effective platinum-based chemotherapeutic agent used against various malignancies, has numerous side effects. Ganoderma lucidum is a traditional Chinese medicine with extensive historical use and proven biological activity. This study investigated the effects of G. lucidum on cisplatin-induced nephrotoxicity and gastrointestinal toxicity.
Materials And Methods: RAW264.7 cells were treated with cisplatin, G. lucidum, or both. Cytotoxicity and antioxidant capacity were measured. Slc:ICR (ICR) mice were treated with cisplatin, G. lucidum, or both. The survival rate and physiological data were measured.
Results: G. lucidum suppressed cisplatin-induced cytotoxicity and apoptosis in RAW264.7 cells. G. lucidum suppressed cisplatin-induced nephrotoxicity and gastrointestinal toxicity via its antioxidant effects in ICR mice.
Conclusion: The suppressive mechanism of G. lucidum may be mediated via its antioxidant effects. These findings indicate its potential to reduce the side effects of cisplatin.
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| http://dx.doi.org/10.21873/anticanres.17183 | DOI Listing |
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