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Assessing the Efficacy of Acanthoic Acid Isolated from Nakai in Male Infertility: An In Vivo and In Silico Approach. | LitMetric

Assessing the Efficacy of Acanthoic Acid Isolated from Nakai in Male Infertility: An In Vivo and In Silico Approach.

Curr Issues Mol Biol

Department of Biology Education, Teachers College and Institute for Phylogenomics and Evolution, Kyungpook National University, Daegu 41566, Republic of Korea.

Published: July 2024

AI Article Synopsis

Article Abstract

Acanthoic acid, a diterpene isolated from the root bark of Nakai, possesses diverse pharmacological activities, including anti-inflammatory, anti-diabetic, gastrointestinal protection, and cardiovascular protection. This study is the first to investigate the egg-hatching rates of affected by acanthoic acid. Notably, male flies supplemented with 10 μM acanthoic acid exhibited a strong increase in hatching rates compared with controls under adverse temperature conditions, suggesting a potential protective effect against environmental stressors. Molecular docking simulations revealed the binding affinities and specific interactions between acanthoic acid and proteins related to male infertility, including SHBG, ADAM17, and DNase I, with binding affinity values of -10.2, -6.8, and -5.8 kcal/mol, respectively. Following the docking studies, molecular dynamic simulations were conducted for a duration of 100 ns to examine the stability of these interactions. Additionally, a total binding energy analysis and decomposition analysis offered insights into the underlying energetic components and identified key contributing residues.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11276288PMC
http://dx.doi.org/10.3390/cimb46070440DOI Listing

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