AI Article Synopsis
- The study aimed to create silver quantum clusters stabilized by serum proteins from different hosts (bovine, human, and murine) to evaluate their safety and effectiveness as antibacterial agents.
- Ag-QCNS showed strong antibacterial properties, particularly against antibiotic-resistant strains, and demonstrated high biocompatibility and hemocompatibility in preclinical tests with mice over a 28-day period.
- The antibacterial mechanism involved the generation of reactive oxygen species (ROS) and damage to bacterial membranes, suggesting that Ag-QCNS could serve as a promising next-generation treatment option for antibiotic resistance.
Article Abstract
To synthesize host-specific serum protein stabilized silver quantum clusters and assess their preclinical safety as potential antibacterial agents. Ag-QC-NanoSera (Ag-QCNS) were synthesized using bovine, human and murine sera. Antibacterial efficacy was evaluated against (including antibiotic-resistant strain), and . Biocompatibility, hemocompatibility and antibacterial mechanism were also investigated. Preclinical safety and biodistribution of autologous Ag-QCNS were assessed in BALB/c mice over 28 days. Ag-QCNS showed high biocompatibility, hemocompatibility and high antibacterial activity at ∼12.72 μg/ml Ag equivalent. Intracellular ROS and bacterial membrane damage were confirmed as antibacterial mechanism. Ag-QCNS were established as preclinically safe. Ag-QCNS demonstrate potential as next-generation host-specific nanotheranostic antibacterial agents, enhancing the safety and efficacy while combating antibiotic resistance.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11418211 | PMC |
| http://dx.doi.org/10.1080/17435889.2024.2374231 | DOI Listing |
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