AI Article Synopsis

  • Porokeratosis variants are uncommon skin conditions that can often be misdiagnosed, mimicking more common skin issues.
  • A new technology called line-field confocal optical coherence tomography (LC-OCT) allows for non-invasive imaging of the skin, providing detailed views up to 500µm deep.
  • In a study with 54 patients, LC-OCT showed high reliability in diagnosing porokeratosis variants and identified unique features not visible in traditional histology, suggesting it could help avoid unnecessary biopsies.

Article Abstract

Background: Porokeratosis variants are relatively rare and can be clinically misdiagnosed with several common papulokeratotic mimickers. Line-field confocal optical coherence tomography (LC-OCT) is a new technology able to explore the skin in vivo up to a depth of 500 µm.

Objectives: To investigate the role of LC-OCT in the diagnosis of many porokeratosis variants in a preliminary study.

Method: In total, 130 LC-OCT images were obtained from 98 patients, 45 affected by a porokeratosis variant (69 images) and 53 with a mimicker condition (61 images).

Results: We found almost perfect interobserver agreement for LC-OCT image interpretation and perfect correspondence with the findings from histological slides. In addition, a series of morphological in vivo and three-dimensional features related to the cornoid lamella were detected by LC-OCT that were not visible from the histology.

Conclusions: This device can be proposed to assist with rapid bedside noninvasive differentiation of porokeratosis variants from their mimickers, possibly sparing incisional biopsy in patients where the diagnosis is uncertain.

Download full-text PDF

Source
http://dx.doi.org/10.1093/ced/llae285DOI Listing

Publication Analysis

Top Keywords

porokeratosis variants
12
line-field confocal
8
confocal optical
8
optical coherence
8
coherence tomography
8
diagnosis porokeratosis
8
porokeratosis
5
lc-oct
5
tomography differential
4
differential diagnosis
4

Similar Publications

Porokeratosis ptychotropica: Case reports and literature review.

Ann Dermatol Venereol

December 2024

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China. Electronic address:

Porokeratosis ptychotropica (PP) is a rare variant of porokeratosis that frequently mimics the clinical manifestations of various squamoproliferative disorders. It lacks a specific definition and adequate understanding. Diagnosis is difficult clinically and remains controversial in some published cases.

View Article and Find Full Text PDF

Porokeratoses-A Rare Group of Dermatoses.

Medicina (Kaunas)

November 2024

Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35010 Rzeszow, Poland.

Porokeratoses represent a rare group of skin diseases characterized by abnormal keratinization. The condition may have a genetic background and can be triggered by environmental factors, including UV exposure and infections. Several clinical variants of porokeratosis can be distinguished, including Mibelli's porokeratosis, disseminated superficial actinic porokeratosis, superficial disseminated porokeratosis, and porokeratosis palmaris plantaris et disseminata.

View Article and Find Full Text PDF

Malignant Transformation in Porokeratosis Ptychotropica: A Systematic Review.

Acta Derm Venereol

October 2024

Department of Dermatology, National University Hospital, Singapore; Department of Medicine, National University of Singapore, Singapore.

Porokeratosis ptychotropica (PP) is a rare and unusual variant of porokeratosis. There is a dearth of information on the natural history, epidemiology, and optimal treatment options. This study aimed to characterize the worldwide distribution, epidemiology, clinical features, and treatments attempted for all reported cases of porokeratosis ptychotropica.

View Article and Find Full Text PDF

A Clinico-Epidemiological Study on Porokeratosis.

Indian J Dermatol

August 2024

Department of Dermatology, Mysore Medical College and Research Institute, Mysore, Karnataka, India.

Article Synopsis
  • Porokeratosis (PK) is a chronic skin condition that presents as elevated, hyperkeratotic papules or plaques with a distinct raised border, linked to mutations in the mevalonate kinase enzyme.
  • The study involved 11 patients, mostly females, with Mibelli's type being the most common form observed; diagnostic techniques included clinical evaluation, dermoscopy indicating a double-marginated border, and histopathological examination showing the cornoid lamella.
  • Regular monitoring is essential for early detection of potential malignant changes in PK variants, emphasizing the importance of using dermoscopy for non-invasive diagnosis.
View Article and Find Full Text PDF
Article Synopsis
  • Porokeratosis includes various hereditary and acquired skin disorders that involve the abnormal growth of skin cells known as keratinocytes.
  • These disorders show different symptoms but share a common feature in their tissue structure called the cornoid lamella.
  • This study reveals a unique case of disseminated superficial porokeratosis linked to mutations in the MVD gene, enhancing our knowledge of its genetic causes and potential treatment options.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!