AI Article Synopsis

  • The successful elimination of leftover tumor cells is crucial to prevent cancer spread and recurrence, and an advanced nanoplatform could enhance cancer treatment effectiveness.* -
  • The study introduces a novel nanoplatform called DSF-CuS@TA, which is designed to release therapeutic agents in response to specific triggers like pH changes and near-infrared light, enabling a "triple attack" strategy against tumors.* -
  • Results indicate that combining DSF-based chemotherapy with NIR-II phototherapy using this intelligent nanoplatform can significantly improve tumor destruction, offering a promising new approach to cancer treatment.*

Article Abstract

Effectively and completely eliminating residual tumor cells is the key to reducing the risk of tumor metastasis and recurrence. Designing an "ideal" nanoplatform for programmable cancer therapy has great prospects for completely eliminating residual tumor cells. Herein, an intelligent nanoplatform of disulfiram (DSF)-loaded CuS-tannic acid nanohexahedrons (denoted as "DSF-CuS@TA") with thermal- and pH-sensitive degradation, as well as near-infrared (NIR-II) phototherapeutics properties, was constructed. And then, it was employed for DSF toxification activation programmable "triple attack" cancer therapy. After accumulating in the tumor, DSF-CuS@TA first releases the loaded Cu(DTC), and simultaneously degrades and releases Cu and DSF under mildly acidic stimulation to trigger instant intratumoral Cu(DTC) chelation, thereby achieving the "first strike." Next, under irradiation by a NIR-II laser, light energy is converted into heat to generate NIR-II photothermal therapy, thereby achieving the second strike. Subsequently, under thermal stimulation, DSF-CuS@TA degrades further, triggering the chelation of Cu(DTC) for a second time to reach the third strike. As expected, and studies showed that the synergistic integration of DSF-based programmed chemotherapy and NIR-II phototherapeutics could achieve effective tumor removal. Therefore, we propose a novel type of programmed therapy against cancer by designing a nanoplatform "nontoxicity-to-toxicity" chemical chelation transformation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268515PMC
http://dx.doi.org/10.1039/d3sc05300hDOI Listing

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