AI Article Synopsis
- Older major depressive disorder (MDD) patients often experience more complex symptoms and a high prevalence (86.1%) of abnormal lipid metabolism (ALM).
- A study of 266 older, first-episode, drug-naïve MDD patients revealed that those with ALM had longer illness duration and more severe depression symptoms than those without ALM.
- Regular lipid assessments are important in managing the health of older MDD patients, as specific clinical characteristics are linked to ALM.
Article Abstract
Background: Older major depressive disorder (MDD) patients have more complex clinical symptoms and higher abnormal lipid metabolism (ALM) rates. This study aimed to compare clinical differences between those with and without ALM in a sample of older first-episode drug naïve (FEDN) patients.
Methods: We recruited 266 older MDD patients. Socio-demographic variables, clinical data, and lipid parameters were obtained. The Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), and the positive subscale of the Positive and Negative Syndrome Scale (PANSS-P) were conducted to evaluate patients' depression, anxiety and psychotic symptoms, respectively.
Results: In this study, we found that the prevalence of comorbid ALM was 86.1% in older MDD patients. Compared with the non-abnormal lipid metabolism (NALM) group, the ALM group had a higher duration of illness, higher clinical global impression of severity scale (CGI-S) and HAMD scores, higher thyroid stimulating hormone (TSH) and glucose levels. Logistic regression analysis indicated that duration of illness (OR = 1.11, P = 0.023, 95%CI = 1.015-1.216) and CGI-S score (OR = 2.28, P = 0.014, 95%CI = 1.18-4.39) were associated with ALM in older MDD patients.
Conclusion: The importance of regular lipid assessment in older MDD patients needs to be taken into account.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270971 | PMC |
| http://dx.doi.org/10.1186/s12888-024-05967-x | DOI Listing |
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