AI Article Synopsis
- Lactylation is a post-translational modification caused by lactate that affects important biological processes like transcription, DNA repair, and mitochondrial function.
- The text explores how lactate and lactylation influence eye development and maintain retinal health.
- Additionally, it highlights the potential link between lactylation and various eye disorders, including myopia, eye tumors, and abnormal blood vessel growth in the retina.
Article Abstract
Lactylation, a post-translational modification (PTM) induced by lactate, has crucial roles in the regulation of transcription, DNA repair, and mitochondrial metabolism. Here, we discuss the role of lactate/lactylation signaling in regulating eye morphogenesis and retinal homeostasis, as well as various ophthalmic disorders, such as myopia, intraocular malignancies, and retinal angiogenesis.
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| http://dx.doi.org/10.1016/j.molmed.2024.07.001 | DOI Listing |
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