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Relationship between sleep disorders and information processing speed in multiple sclerosis.
Clinics (Sao Paulo)
January 2025
Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:
Objectives: It is estimated that up to 65 % of pwMS (people with multiple sclerosis) experience varying degrees of cognitive impairment, the most commonly affected domain being Information Processing Speed (IPS). As sleep disturbance is a predictor of detriments in IPS, the authors aimed to study the association between the severity of Restless Legs Syndrome (RLS) and Obstructive Sleep Apnea (OSA) symptoms with IPS in pwMS.
Methods: In a cross-sectional study, the authors enrolled people with relapsing-remitting and secondary progressive MS referred to the comprehensive MS center of Kashani Hospital in Isfahan, Iran.
Botulinum Therapy for Pain Caused by Spasticity in Advanced Stages of Brain Tumor in Adolescents: A Case Report.
Clin Med Insights Case Rep
January 2025
Department of Rehabilitation, Nara Prefectural General Medical Center, Nara, Japan.
Background: Spasticity is an upper motor neuron syndrome that exacerbates motor paralysis and is rarely associated with pain. This report elucidates the management of drug-resistant pain attributed to an adolescent brain tumor using botulinum therapy.
Case Presentation: A 15-year-old female patient experienced dizziness, developed muscle weakness in her upper extremities, and was diagnosed with diffuse glioblastoma of the pons.
Psychosis associated with cannabis withdrawal: systematic review and case series.
Br J Psychiatry
December 2024
Department of Psychiatry, University of Oxford, UK.
Article Synopsis
- Abruptly stopping heavy cannabis use can lead to withdrawal symptoms like irritability, anxiety, insomnia, and in some cases, trigger acute psychosis.
- A systematic review and a comprehensive analysis of psychiatric records identified a total of 112 individuals whose first episodes of psychosis were linked to cannabis withdrawal.
- Continued cannabis use after experiencing a psychotic episode significantly increases the risk of relapse compared to individuals who choose to abstain.
Restless legs syndrome associated with teriflunomide use in two patients with multiple sclerosis.
Clin Neurol Neurosurg
January 2025
Tokat Gaziosmanpaşa University, Faculty of Medicine, Department of Neurology, Tokat, Turkey.
Article Synopsis
- Teriflunomide is an oral medication for treating relapsing-remitting multiple sclerosis by inhibiting T and B lymphocyte proliferation.
- Common side effects include headache, elevated liver enzymes, hair thinning, and joint pain.
- Two reported cases show that patients developed restless legs syndrome after starting teriflunomide, highlighting the need to monitor for this potential side effect in MS patients.
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